Research Perspectives:

Target HER four in breast cancer?

Gero Brockhoff _

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Oncotarget. 2019; 10:3147-3150. https://doi.org/10.18632/oncotarget.26867

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Gero Brockhoff1

1 Department of Gynecology and Obstetrics, University Medical Center Regensburg, Regensburg, Germany

Correspondence to:

Gero Brockhoff, email: [email protected]

Keywords: HER4; breast cancer

Received: March 01, 2019    Accepted: April 02, 2019    Published: May 07, 2019


The HER4 receptor tyrosine kinase is known to have promiscuous activity in malignant cells, last but not least in breast cancer. Evidently, the prognostic and predictive impact of HER4 expression depends on the expression of different receptor isotypes, the way of receptor activation (ligand dependent vs. independent), and on the complex interaction of the HER4 intracellular domain (4ICD) with intracellular regulative molecules which results in either oncogenic or rather tumor suppressive HER4 activity. Recent data suggest that HER4 unfavorably affects the endocrine treatment of postmenopausal breast cancer patients with tamoxifen and therefore might represent an additional therapeutic target in luminal breast cancer.

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