MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes

Maria M. Simile1, Graziella Peitta1, Maria L. Tomasi2, Stefania Brozzetti3, Claudio F. Feo4, Alberto Porcu4, Antonio Cigliano5, Diego F. Calvisi1, Francesco Feo1 and Rosa M. Pascale1

1Department of Medical, Surgical and Experimental Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy

2Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA

3Department of Surgery “Pietro Valdoni”, University of Rome “La Sapienza”, Rome, Italy

4Department of Medical, Surgical and Experimental Sciences, Division of Surgery, University of Sassari, Sassari, Italy

5Institute of Pathology, University of Regensburg, Regensburg, Germany

Correspondence to:

Rosa M. Pascale, email: [email protected]

Keywords: methionine metabolism; methyladenosyltransferases; S-adenosylmethionine; HCC prognosis; HCC therapy

Received: November 08, 2018     Accepted: March 04, 2019     Published: PUBLISHED_DATE