Cancer associated fibroblasts in hematological malignancies
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Lizzia Raffaghello1, Angelo Vacca2, Vito Pistoia1, Domenico Ribatti3
1Laboratorio di Oncologia, Istituto G. Gaslini, Genova, Italy
2Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
3Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy, National Cancer Institute “Giovanni Paolo II”, Bari, Italy
Domenico Ribatti, e-mail: [email protected]
Keywords: cancer associated fibroblasts, mesenchymal stromal cells, hematological malignancies, tumor microenvironment
Received: September 03, 2014 Accepted: October 27, 2014 Published: December 06, 2014
Tumor microenvironment plays an important role in cancer initiation and progression. In hematological malignancies, the bone marrow represents the paradigmatic anatomical site in which tumor microenvironment expresses its morphofunctional features. Among the cells participating in the composition of this microenvironment, cancer associated fibrobasts (CAFs) have received less attention in hematopoietic tumors compared to solid cancers. In this review article, we discuss the involvement of CAFs in progression of hematological malignancies and the potential targeting of CAFs in a therapeutic perspective.
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