Cancer associated fibroblasts in hematological malignancies

Lizzia Raffaghello _, Angelo Vacca, Vito Pistoia and Domenico Ribatti

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Oncotarget. 2015; 6:2589-2603. https://doi.org/10.18632/oncotarget.2661

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Lizzia Raffaghello1, Angelo Vacca2, Vito Pistoia1, Domenico Ribatti3

1Laboratorio di Oncologia, Istituto G. Gaslini, Genova, Italy

2Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy

3Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy, National Cancer Institute “Giovanni Paolo II”, Bari, Italy

Correspondence to:

Domenico Ribatti, e-mail: [email protected]

Keywords: cancer associated fibroblasts, mesenchymal stromal cells, hematological malignancies, tumor microenvironment

Received: September 03, 2014     Accepted: October 27, 2014     Published: December 06, 2014


Tumor microenvironment plays an important role in cancer initiation and progression. In hematological malignancies, the bone marrow represents the paradigmatic anatomical site in which tumor microenvironment expresses its morphofunctional features. Among the cells participating in the composition of this microenvironment, cancer associated fibrobasts (CAFs) have received less attention in hematopoietic tumors compared to solid cancers. In this review article, we discuss the involvement of CAFs in progression of hematological malignancies and the potential targeting of CAFs in a therapeutic perspective.

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