Contribution of MSMB promoter region gene polymorphism to early-onset prostate cancer risk in Mexican males
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Silvia Juliana Trujillo-Cáceres1, Luisa Torres-Sánchez1, Ana I. Burguete-García2, Yaneth Citlalli Orbe Orihuela2, Ruth Argelia Vázquez-Salas3, Esmeralda Álvarez-Topete4 and Rocío Gómez4
1Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública (INSP), Cuernavaca, Morelos, Mexico
2Centro de Investigación en Enfermedades Infecciosas, INSP, Cuernavaca, Morelos, Mexico
3Conacyt-Centro de Investigación en Salud Poblacional, INSP, Cuernavaca, Morelos, Mexico
4Departamento de Toxicología, Cinvestav-IPN, Mexico City, Mexico
Luisa Torres-Sánchez, email: [email protected]
Keywords: genetic polymorphisms; MSMB; prostate cancer; rs10993994; sexually transmitted diseases
Received: July 13, 2018 Accepted: December 16, 2018 Published: January 22, 2019
Sexually transmitted infections and its contribution to prostate cancer (PC) development have been relevant in different populations. MSMB gene polymorphism (rs10993994) has exhibited an association both with PC as well as the susceptibility to sexually transmitted infections. Hitherto, these conditions have been not studied in Mexico yet, neither if sexually transmitted infections could modify the MSMB and PC association. Herein, socio-demographic features, sexually transmitted infections records, the reproductive backgrounds, and the genetic characterisation were analysed in 322 incident PC cases and 628 population healthy controls from Mexico City. Whole PC, early-onset PC (PC at < 60 years old), late-onset PC (≥ 60 years old), and PC aggressiveness were used to evaluate the genetic variants contribution to PC risk using unconditional logistic regression models. Overall, none associations between the allelic variants of rs10993994 polymorphisms with whole and PC aggressiveness were found. Howbeit, the TT genotype carriers presented the highest susceptibility to develop early-onset PC (OR = 2.66; 95% CI = 1.41, 5.04; p = 0.03) than CC+CT carriers, both with codominant and recessive models. Although none association between whole PC and MSMB gene polymorphism was found, our results were reinforced by prior studies in European descendent populations, suggesting a contribution between rs10993994 and early-onset PC development.
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