Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas
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Ciro Soares1, Thayná Melo de Lima Morais1, Roman Carlos2, Fernanda Viviane Mariano1,3, Albina Altemani1,3, Maria Goretti Freire de Carvalho4, Marcelo Brum Corrêa5, Rodrigo Ribas Dias dos Reis6, Luciana Schultz Amorim7, Oslei Paes de Almeida1 and Jacks Jorge1
1Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil
2Pathology Division, Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, Guatemala
3Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil
4Private Pathology Service, Natal, Rio Grande do Norte, Brazil
5Head and Neck Surgery Department - Oncology Center (CEON), Fornecedores de Cana Hospital, Piracicaba, São Paulo, Brazil
6Oncology Surgery Department - Cancer Center (CECAN), Santa Casa Hospital, Piracicaba, São Paulo, Brazil
7Institute of Pathological Anatomy, Piracicaba, São Paulo, Brazil
Ciro Soares, email: [email protected]
Keywords: cutaneous melanomas; mucosal melanomas; p-Akt1; immunohistochemistry; prognosis
Received: August 08, 2018 Accepted: November 26, 2018 Published: December 18, 2018
Melanomas are highly aggressive tumours derived from melanocytes, which occur most commonly in the skin. Occasionally, these tumours may appear in oral and sinonasal mucous membranes. In this study, we performed a comparative analysis of the Phosphorylated Akt1 (p-Akt1) expression in 144 patients affected by cutaneous (CM), 34 oral cavity (OM), and 31 sinonasal melanomas (SNM). Similar to the metastatic cutaneous melanomas, p-Akt1 was overexpressed in 17/34 of the oral cavity and 20/31 of the sinonasal melanomas. In addition, the p-Akt1-nuclear expression was associated with poorer cancer-specific survival in cutaneous (P < .0001), oral (P < .0001), and sinonasal (P = .001) melanomas. Multivariate analysis showed p-Akt1 to be an independent prognostic marker in oral (P = .041) and sinonasal (P < .0001) melanomas patients. In conclusion, p-Akt1 overexpression is an independent prognostic marker in mucosal melanomas and is significantly up-regulated in sinonasal melanomas. As both mucosal and metastatic cutaneous melanomas showed high frequency of p-Akt1 expression, these findings suggest that mucosal melanomas have a biological behaviour, similar to the aggressive cutaneous melanomas.
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