Oncotarget

Research Papers:

β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage

Antonino Tuttolomondo _, Rosario Maugeri, Elisabetta Orlando, Giulio Giannone, Francesco Ciccia, Aroldo Rizzo, Domenico Di Raimondo, Francesca Graziano, Rosaria Pecoraro, Carlo Maida, Irene Simonetta, Anna Cirrincione, Francesca Portelli, Francesca Corpora, Domenico Gerardo Iacopino and Antonio Pinto

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Oncotarget. 2018; 9:34699-34707. https://doi.org/10.18632/oncotarget.26165

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Abstract

Antonino Tuttolomondo1, Rosario Maugeri4, Elisabetta Orlando2, Giulio Giannone2, Francesco Ciccia3, Aroldo Rizzo5, Domenico Di Raimondo1, Francesca Graziano4, Rosaria Pecoraro1, Carlo Maida1, Irene Simonetta1, Anna Cirrincione1, Francesca Portelli2, Francesca Corpora1, Domenico Gerardo Iacopino4 and Antonio Pinto1

1Internal Medicine and Stroke Care Ward, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy

2Human Pathology Section, Human Pathology Section, Department of Health Sciences, University of Palermo, Palermo, Italy

3Rheumathology Ward, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy

4Neurosurgery Ward, Dipartimento di BioMedicina Sperimentale e Neuroscienze Cliniche, Università degli Studi di Palermo, Palermo, Italy

5Human Pathology Section, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy

Correspondence to:

Antonino Tuttolomondo, email: bruno.tuttolomondo@unipa.it

Keywords: β-amyloid; superficial temporal artery; intracerebral haemorrhage; CAAH

Received: February 06, 2018     Accepted: September 03, 2018     Published: October 05, 2018

ABSTRACT

Background: Cerebral Amyloid Angiopathy has been indicated as an important cause of spontaneous non-hypertensive intracerebral haemorrhage (ICH).

Aims: to analyze the presence of β-amyloid deposit in the temporal artery of consecutive patients with ICH in comparison to control subjects and its relation to APO-E haplotype frequency.

Methods: We enrolled consecutive patients admitted to Neurosurgery Ward of University Hospital “P. Giaccone” of Palermo with a diagnosis of spontaneous non hypertensive ICH and as control 12 subjects without brain haemorrhage. Biopsy of superficial temporal artery has been performed and β-amyloid deposit was quantified.

Results: Among 25 subjects with ICH, 10 (40%) had APOE epsilon 2 allele and among these subjects 7 (70%) showed amyloid accumulation on temporal artery specimens, 8 (32%) subjects had APOE epsilon 3 allele and among these subjects only 2 (25%) showed amyloid accumulation on temporal artery specimens, whereas 7 (28%) had APOE epsilon 4 allele and of these, 7 (100%) showed amyloid accumulation on temporal artery specimens. At multivariable logistic regression analysis for the presence of amyloid, predictive factors for the presence of amyloid in temporal artery biopsies were: age, hypertension, intralobar site of haemorrhage, APOE epsilon 2 and APOE epsilon 4 alleles.

Discussion: Our findings of a higher frequency of amyloid deposition in temporal artery specimens in subjects with spontaneous intracerebral haemorrhage indicate a possible role of temporal artery as a possible diagnostic site of biopsy in subjects at high risk to develop intracranial haemorrhage related to Cerebral Amyloid Angiopathy.


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