Oncotarget

Research Papers:

Abdominal obesity and prostate cancer risk: epidemiological evidence from the EPICAP study

Céline Lavalette, Brigitte Trétarre, Xavier Rebillard, Pierre-Jean Lamy, Sylvie Cénée and Florence Menegaux _

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Oncotarget. 2018; 9:34485-34494. https://doi.org/10.18632/oncotarget.26128

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Abstract

Céline Lavalette1, Brigitte Trétarre2, Xavier Rebillard3, Pierre-Jean Lamy3,4, Sylvie Cénée1 and Florence Menegaux1

1Université Paris-Saclay, Université Paris-Sud, CESP (Center for Research in Epidemiology and Population Health), Inserm, Team Cancer and Environment, Villejuif, France

2Registre des Tumeurs de l’Hérault, ICM, Montpellier, France

3Service Urologie, Clinique Beau Soleil, Montpellier, France

4Institut Médical d’Analyse Génomique-Imagenome, Montpellier, France

Correspondence to:

Florence Menegaux, email: Florence.menegaux@inserm.fr

Keywords: prostate cancer; obesity; waist circumference; waist-hip ratio; body mass index

Received: March 24, 2018     Accepted: September 03, 2018     Published: October 02, 2018

ABSTRACT

Obesity is associated with an increased risk of several cancers, but inconsistent results have been observed between body mass index (BMI) and prostate cancer (PCa) risk. However, some associations have been reported with other indicators such as waist circumference (WC) and waist-hip ratio (WHR). We investigated the role of anthropometric indicators in PCa risk based on data from the Epidemiological study of Prostate Cancer (EPICAP).

EPICAP is a population-based case-control study that included 819 incident PCa in 2012–2013 and 879 controls frequency matched by age. Anthropometric indicators (weight, height, WC, and hip circumference) have been measured at interview. Logistic regression models were used to assess odds ratios (ORs) for the associations between anthropometric indicators (BMI, WC and WHR) and PCa risk.

We observed a slight, but not significant increased risk of PCa for men with a WC > 94 cm (OR 1.20, 95% CI 0.92–1.56) and for men with a WHR ≥ 0.95 (OR 1.30, 95% CI 1.00–1.70 between 0.95 and 1.00, OR 1.25, 95% CI 0.96–1.61 above 1.00). Associations were more pronounced after adjustment and stratification for BMI and in men with aggressive PCa.

Our results suggest that abdominal obesity may be associated with an increased risk of PCa, especially aggressive PCa.


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