Absence of correlation between radiation-induced CD8 T-lymphocyte apoptosis and sequelae in patients with prostate cancer accidentally overexposed to radiation
Metrics: PDF 486 views | HTML 1187 views | ?
Guillaume Vogin1,2,*, Jean-Louis Merlin3,4,5,*, Alexandra Rousseau6, Didier Peiffert4, Alexandre Harlé1,2,3, Marie Husson3, Labib El Hajj4, Mihai Levitchi4, Tabassome Simon6 and Jean-Marc Simon7
1Institut de Cancérologie de Lorraine, Département de Radiothérapie, 54500 Vandœuvre-lès-Nancy, France
2UMR 7365 CNRS-Université de Lorraine, 54500 Vandœuvre-lès-Nancy, France
3Université de Lorraine, Faculté de Pharmacie, 54000 Nancy, France
4CNRS UMR 7039 CRAN Université de Lorraine, 54500 Vandœuvre-lès-Nancy, France
5Institut de Cancérologie de Lorraine, Service de Biopathologie, 54500 Vandœuvre-lès-Nancy, France
6APHP, Unité de Recherche Clinique de l'Est Parisien (URC-Est), Hôpital Saint Antoine, 75012 Paris, France
7APHP, Hôpital Universitaire de la Pitié Salpêtrière, Service de Radiothérapie, 75013 Paris, France
*These authors have contributed equally to this work
Guillaume Vogin, email: email@example.com
Keywords: late radiation-induced toxicity; radiation-induced lymphocyte apoptosis; prostate cancer; Epinal adverse event; individual radiation sensitivity
Received: June 23, 2018 Accepted: August 04, 2018 Published: August 24, 2018
Purpose: 454 patients with prostate adenocarcinoma were accidentally overexposed to radiation in Epinal hospital, France, between August 1999 and January 2007. We aimed toevaluate whether radiation-induced CD4 or CD8 T-lymphocyte apoptosis (RILA) correlates with the severity of radiation toxicity.
Methods: Between 2007 and 2013, all patients who received more than 108% of the prescribed radiation dose, after correction of the treatment plan, were convened, and blood was sampled at 6-months follow-up. Maximal Digestive toxicity (MDT) and maximal urinary toxicity (MUT) were graded using the Common Terminology Criteria for Adverse Events (NCI-CTCAE) v3.0 scale. RILA was assessed using flow cytometry.
Results: 245 patients were included in our study. After a median follow-up of 4.8 years, the MDT and MUT reached grade 3-4 in 37 patients and 56 patients, respectively. Patients with prostatectomy exhibited a statistically higher grade of MUT compared with those treated with definitive radiotherapy (p=0.03). The median RILA values were 11.8% and 15.3% for CD4 and CD8 T-lymphocytes, respectively. We found no significant correlation between CD4 or CD8 RILA and either MDT or MUT.
Conclusion: RILA does not correlate with the inter-individual variation in MDT or MUT in the largest cohort of patients overexposed to radiation. The magnitude of the overdosage probably overrides biological predictors of toxicity, including individual radiosensitivity.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.