Oncotarget

Research Papers:

Race and nodal disease status are prognostic factors in patients with stage IVB cervical cancer

Shin Nishio _, Koji Matsuo, Koji Yonemoto, Mototsugu Shimokawa, Masayuki Hosaka, Michiko Kodama, Takahito M. Miyake, Kimio Ushijima, Toshiharu Kamura, Shannon N. Westin, Pamela T. Soliman and Robert L. Coleman

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Oncotarget. 2018; 9:32321-32330. https://doi.org/10.18632/oncotarget.25962

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Abstract

Shin Nishio1,2, Koji Matsuo3,4, Koji Yonemoto5, Mototsugu Shimokawa6, Masayuki Hosaka1, Michiko Kodama1, Takahito M. Miyake1, Kimio Ushijima2, Toshiharu Kamura2, Shannon N. Westin1, Pamela T. Soliman1 and Robert L. Coleman1

1Department of Gynecologic Oncology and Reproductive Medicine, University of Texas, MD Anderson Cancer Center, Houston, TX, USA

2Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Fukuoka, Japan

3Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA

4Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA

5Biostatistics Center, Kurume University, Kurume, Fukuoka, Japan

6Clinical Research Institute, National Kyushu Cancer Center, Fukuoka, Japan

Correspondence to:

Shin Nishio, email: shinshin@med.kurume-u.ac.jp

Keywords: stage IVB; cervical cancer; prognostic factor; African-American; para-aortic chain

Received: March 19, 2018    Accepted: July 27, 2018    Published: August 17, 2018

ABSTRACT

Background: Patients presenting with stage IVB cervical cancer pose a significant clinical challenge. While previous studies described several poor prognostic factors, they were limited by small sample sizes. The aim of this study was to identify clinicopathological prognostic factors in a large sample of patients with stage IVB cervical cancer at a single institution.

Methods: Patients with primary stage IVB cervical cancer diagnosed between 1992 and 2011 were extracted from a search of the MD Anderson Cancer Center registry. Clinicopathological data retrieved from their medical records included demographics (age and race), tumor characteristics (primary lesion size, grade, and histology), TNM classification, and metastatic site (nodal/organ). Treatment approach (radiation, chemotherapy, or both) and intent (palliation or curative) were recorded. Survival rates were evaluated using the Kaplan-Meier method. Cox proportional hazards regression was used to model the association between key variables and overall survival (OS).

Results: Two hundred sixty-six patients with stage IVB cervical cancer were identified. Their median OS was 12.7 months. The hazard ratio for African-Americans vs. patients with other ethnicities was 1.76 (95% confidence interval [CI], 1.18–2.54, P=0.0063), and that for patients with para-aortic nodes alone vs. more extensive metastases was 0.37 (95% CI, 0.26–0.51, P<0.0001). Other clinicopathological factors were not significantly associated with survival.

Conclusions: African-American race was an independent adverse prognostic factor in this cohort. On the other hand, nodal disease in the para-aortic chain alone predicted a favorable prognosis.


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