Oncotarget

Research Papers:

Cell-specific plasticity associated with integrative memory of triple sensory signals in the barrel cortex

Jing Feng, Wei Lu, Guang-Yan Wang, Zhao-Ming Zhu, Yan Sun, Kaixin Du and Jin-Hui Wang _

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Oncotarget. 2018; 9:30962-30978. https://doi.org/10.18632/oncotarget.25740

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Abstract

Jing Feng1,2,3,*, Wei Lu1,2,4,*, Guang-Yan Wang4, Zhao-Ming Zhu4, Yan Sun4, Kaixin Du4 and Jin-Hui Wang1,2,3

1Department of Biology, University of Science and Technology China, Hefei, China

2Institute of Biophysics and University of Chinese Academy of Sciences, Beijing, China

3University of Chinese Academy of Sciences, Beijing, China

4Qingdao University, School of Pharmacy, Shandong, China

*These authors contributed equally to this work

Correspondence to:

Jin-Hui Wang, email: jhw@sun5.ibp.ac.cn

Keywords: learning memory; glutamate; GABA; synapse; barrel cortex

Received: September 26, 2017     Accepted: March 06, 2018     Published: July 24, 2018

ABSTRACT

Neuronal plasticity occurs in associative memory. Associative memory cells are recruited for the integration and storage of associated signals. The coordinated refinements and interactions of associative memory cells including glutamatergic and GABAergic neurons remain elusive, which we have examined in a mouse model of associative learning. Paired olfaction, tail and whisker stimulations lead to odorant-induced and tail-induced whisker motions alongside whisker-induced whisker motion. In mice that show this cross-modal associative memory, barrel cortical glutamatergic and GABAergic neurons are recruited to encode the newly learned odor and tail signals alongside the innate whisker signal. These glutamatergic neurons are functionally upregulated, and GABAergic neurons are refined in a homeostatic manner. The mutual innervations between these glutamatergic and GABAergic neurons are upregulated. Therefore, the co-activations of sensory cortices by pairing the input signals recruit their glutamatergic and GABAergic neurons to be associative memory cells, which undergo coordinated refinement among glutamatergic and GABAergic neurons as well as homeostatic plasticity among subcellular compartments in order to drive these cells toward the optimal state for the integrative storage of associated signals.


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