Bone mineral density and microarchitecture linkages with micro- and macro-vascular impairments at the hand in systemic sclerosis: an HRpQCT study
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Lucie Atlan1, Nada Ibrahim-Nasser2,3, Antoine Valery4, Carole Bazzi5, François Rollin2, Guido Bens6, Mathilde Marot1, Eric Estève3,6 and Eric Lespessailles2,3
1Department of Rheumatology, University Hospital of Tours, Tours, France
2Department of Rheumatology, Regional Hospital of Orleans, Orleans, France
3University of Orleans, I3MTO Laboratory, Orleans, France
4Department of Medical Information, Regional Hospital of Orleans, Orleans, France
5Department of Vascular Medicine, Regional Hospital of Orleans, Orleans, France
6Department of Dermatology, Regional Hospital of Orleans, Orleans, France
Eric Lespessailles, email: [email protected]
Keywords: systemic sclerosis; high-resolution peripheral quantitative computed tomography; bone microarchitecture; vasculopathy; nailfold videocapillaroscopy
Received: March 24, 2018 Accepted: June 12, 2018 Published: June 29, 2018
Objective: To investigate the link between bone alteration and micro- and macro-vascular disease in patients with systemic sclerosis (SSc).
Results: 33 SSc patients were included. In univariate analysis, low values of cortical vBMD were significantly associated with a low DBI at the 2nd finger (p = 0.004) and at the 4th (p = 0.002) and with severe capillaroscopic score (p = 0.008). In multivariate analyses, low cortical vBMD was associated with a low DBI at the 4th finger, age and severe capillaroscopic score (adjusted R² = 0.58; p = < 0.001). Low cortical thickness was associated with a low DBI at the 4th finger, severe capillaroscopic score and age (adjusted R² = 0.49, p = < 0.001).
Conclusion: Our study findings showed an association between micro- and macro-vessel damage and altered microarchitectural indices at the radius in SSc.
Methods: We performed a pilot study in female patients with SSc. Microvascular disease was assessed by the capillaroscopic score of Cutolo. Macrovascular involvement was measured by digito-brachial pressure index (DBI) on laser-Doppler at the 2nd and 4th finger. Volumetric bone mineral density (vBMD) and bone microarchitecture involvement were analysed by High-Resolution peripheral Quantitative Computed Tomography (HRpQCT) at the distal radius.
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