Research Papers:

Bone mineral density and microarchitecture linkages with micro- and macro-vascular impairments at the hand in systemic sclerosis: an HRpQCT study

Lucie Atlan, Nada Ibrahim-Nasser, Antoine Valery, Carole Bazzi, François Rollin, Guido Bens, Mathilde Marot, Eric Estève and Eric Lespessailles _

PDF  |  HTML  |  How to cite

Oncotarget. 2018; 9:29484-29494. https://doi.org/10.18632/oncotarget.25681

Metrics: PDF 1292 views  |   HTML 1914 views  |   ?  


Lucie Atlan1, Nada Ibrahim-Nasser2,3, Antoine Valery4, Carole Bazzi5, François Rollin2, Guido Bens6, Mathilde Marot1, Eric Estève3,6 and Eric Lespessailles2,3

1Department of Rheumatology, University Hospital of Tours, Tours, France

2Department of Rheumatology, Regional Hospital of Orleans, Orleans, France

3University of Orleans, I3MTO Laboratory, Orleans, France

4Department of Medical Information, Regional Hospital of Orleans, Orleans, France

5Department of Vascular Medicine, Regional Hospital of Orleans, Orleans, France

6Department of Dermatology, Regional Hospital of Orleans, Orleans, France

Correspondence to:

Eric Lespessailles, email: [email protected]

Keywords: systemic sclerosis; high-resolution peripheral quantitative computed tomography; bone microarchitecture; vasculopathy; nailfold videocapillaroscopy

Received: March 24, 2018     Accepted: June 12, 2018     Published: June 29, 2018


Objective: To investigate the link between bone alteration and micro- and macro-vascular disease in patients with systemic sclerosis (SSc).

Results: 33 SSc patients were included. In univariate analysis, low values of cortical vBMD were significantly associated with a low DBI at the 2nd finger (p = 0.004) and at the 4th (p = 0.002) and with severe capillaroscopic score (p = 0.008). In multivariate analyses, low cortical vBMD was associated with a low DBI at the 4th finger, age and severe capillaroscopic score (adjusted R² = 0.58; p = < 0.001). Low cortical thickness was associated with a low DBI at the 4th finger, severe capillaroscopic score and age (adjusted R² = 0.49, p = < 0.001).

Conclusion: Our study findings showed an association between micro- and macro-vessel damage and altered microarchitectural indices at the radius in SSc.

Methods: We performed a pilot study in female patients with SSc. Microvascular disease was assessed by the capillaroscopic score of Cutolo. Macrovascular involvement was measured by digito-brachial pressure index (DBI) on laser-Doppler at the 2nd and 4th finger. Volumetric bone mineral density (vBMD) and bone microarchitecture involvement were analysed by High-Resolution peripheral Quantitative Computed Tomography (HRpQCT) at the distal radius.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 25681