Research Papers:

IGFBP2 is a potential biomarker in acute kidney injury (AKI) and resveratrol-loaded nanoparticles prevent AKI

Hai-Lun Li _, Zhuan Yan, Zun-Ping Ke, Xiao-Feng Tian, Li-Li Zhong, Yong-Tao Lin, Yong Xu and Dong-Hui Zheng

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Oncotarget. 2018; 9:36551-36560. https://doi.org/10.18632/oncotarget.25663

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Hai-Lun Li1,*, Zhuan Yan2,*, Zun-Ping Ke3,*, Xiao-Feng Tian4, Li-Li Zhong1, Yong-Tao Lin5, Yong Xu1 and Dong-Hui Zheng1

1Department of Nephrology, Huai'an Second People's Hospital and The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, China

2Department of Emergency, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, China

3Department of Cardiology, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai 200240, China

4Department of Thoracic Surgery, Huai'an Second People's Hospital and The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, China

5Jiangsu College of Nursing, Huai'an, Jiangsu 223001, China

*Co-first authors

Correspondence to:

Dong-Hui Zheng, email: [email protected]

Yong Xu, email: [email protected]

Keywords: acute kidney injury; insulin-like growth factor binding protein2; resveratrol-loaded nanoparticles

Received: May 11, 2017     Accepted: August 08, 2017     Published: November 27, 2018


This study aims to determine whether insulin-like growth factor binding protein2 (IGFBP2) is a useful biomarker for early diagnosis of acute kidney injury (AKI), evaluate the therapeutic effects of resveratrol-loaded nanoparticles (Res-NPs), and investigate the possible underlying mechanisms in a rat model of AKI induced by IRI. Forty male Sprague–Dawley rats were randomly divided into four groups (10 animals per group): sham, IRI control, resveratrol, and Res-NPs injection. Kidney injury and the effects of Resveratrol and Res-NPs were determined by histological examination, renal function, cell apoptosis profile, and gene expression. Changes in IGFBP2 were similar with the pattern of well-known renal biomarkers, namely, kidney injury molecule 1 and neutrophil gelatinase-associated lipocalin, in all groups. Compared with the IRI control and resveratrol groups, the Res-NPs groups displayed significantly reduced apoptotic rate, reactive oxygen species level, and malondialdehyde content, downregulated protein expression levels of Caspase3 and Bax with increased antioxidant glutathione peroxidase level, and upregulated expression of Bcl-2 protein. Thus, IGFBP2 may serve as a promising novel biomarker of AKI, and Res-NPs may prevent kidney injury from ischemia/reperfusion in a rat model.

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