Case Reports:

Papillary thyroid microcarcinoma (Black Ink)

Ersilio Trapanese, Carmine De Bartolomeis, Basilio Angrisani and Giulio Tarro _

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Oncotarget. 2018; 9:29275-29283. https://doi.org/10.18632/oncotarget.25621

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Ersilio Trapanese1, Carmine De Bartolomeis2, Basilio Angrisani3 and Giulio Tarro4,5

1Interventional Ultrasound of Breast Oncology Screening, ASL Salerno, Salerno, Italy

2Endocrine Surgery and General Surgery Specialist, University Pisa, Pisa, Italy

3Anatomical Pathology Specialist, University Hospital of Campania “L. Vanvitelli”, Naples, Italy

4President Foundation T. & L. de Beaumont Bonelli for Cancer Research, Naples, Italy

5Chairman of the VirusSphere World Academy of Biomedical Technologies (WABT) UNESCO, Paris, France

Correspondence to:

Giulio Tarro, email: [email protected]

Keywords: ultrasonography; ADF; FNAC; thyroid microcarcinoma; Black Ink

Received: March 07, 2018    Accepted: May 25, 2018    Published: June 26, 2018


We report a case of a 58-year-old Caucasian woman affected by papillary thyroid microcarcinoma (PTMC) of the left-lobe of the gland with very small size (Ø 0.3 cm). The characteristics with the Diagnostic Imaging using Ultrasonography, ADF (Advanced Dynamic Flow), and fine-needle-aspiration cytology (FNAC) are discussed, comprising a very small micro-focus of radial shape, with markedly hypoechoic echostructure, irregular margins, supplemented by peripheral vessel formation. It acquires an image which appears similar to a brisk visualization of a dark ink stain in the normal thyroid weave. We call such a pattern “Black Ink” with ultrasonographic image and believe consistent with the infiltrating variant of papillary thyroid microcarcinoma if associated with malignant cytology after FNA.

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