Research Papers:

Intracranial hemangioblastoma – A SEER-based analysis 2004–2013

Ha Son Nguyen _, Ninh B. Doan, Michael Gelsomino, Saman Shabani, Ahmed J. Awad, Mayank Kaushal and Martin M. Mortazavi

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Oncotarget. 2018; 9:28009-28015. https://doi.org/10.18632/oncotarget.25534

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Ha Son Nguyen1,3, Ninh B. Doan1,5, Michael Gelsomino1, Saman Shabani1, Ahmed J. Awad1,4, Mayank Kaushal1 and Martin M. Mortazavi2,3

1Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

2National Skull Base Center, Thousand Oaks, California, USA

3California Institute of Neuroscience, Thousand Oaks, California, USA

4Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

5Department of Neurosurgery, University of South Alabama, Mobile, Alabama, USA

Correspondence to:

Ha Son Nguyen, email: [email protected]

Keywords: intracranial hemangioblastoma; SEER; surgery; radiation

Received: March 28, 2018     Accepted: May 14, 2018     Published: June 15, 2018


Introduction: Intracranial hemangioblastoma (HB) is a rare pathology. Limited data exist regarding its epidemiology.

Methods: With the SEER-18 registry database, information from all patients diagnosed with intracranial HB from 2004 to 2013 were extracted, including age, gender, race, marital status, presence of surgery, extent of surgery, receipt of radiation, tumor size, tumor location, and follow-up data. Age-adjusted incidence rates and overall survival (OS). Cox proportional hazards model was employed for both univariate and multivariate analyses.

Results: A total of 1307 cases were identified. The overall incidence of intracranial hemangioblastoma is 0.153 per 100,000 person-years [95% confidence interval (CI)=0.145–0.162]. Through univariate analysis, age < 40 [hazard ratio (HR)=0.277, p<0.001], no radiation [HR=0.56, p=0.047], and presence of surgery [HR=0.576, p=0.012] are significant positive prognostic factors. Caucasian race [HR=1.42, p=0.071] and female gender [HR=0.744, p=0.087] exhibit noticeable trends towards positive prognosis. Through multivariate analysis, younger age [HR=1.053, p < 0.01], race [HR=1.916, p<0.01], and presence of surgery [HR=0.463, p<0.01 were significant independent prognostic factors.

Conclusion: Clinical factors such as younger age, Caucasian race, and presence of surgery are significant independent factors for overall survival in patients with HBs. Though analysis regarding extent of surgery did not produce a meaningful relationship, this may be related to surgical bias / expertise. Moreover, no validation for radiation therapy was identified, but this may be related to short follow up intervals and the variable growth patterns of HBs.

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