Clinical Research Papers:

Optimal hydration volume among high-risk patients with advanced congestive heart failure undergoing coronary angiography

Shi-Qun Chen, Yong Liu, Wei Jie Bei, Ying Wang, Chong-Yang Duan, Deng-Xuan Wu, Kun Wang, Ping Yan Chen, Ji-Yan Chen, Ning Tan and Li-Wen Li _

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Oncotarget. 2018; 9:23738-23748. https://doi.org/10.18632/oncotarget.25315

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Shi-Qun Chen1,2,*, Yong Liu1,3,*, Wei Jie Bei1,*, Ying Wang3,*, Chong-Yang Duan4,*, Deng-Xuan Wu1,*, Kun Wang1, Ping Yan Chen4, Ji-Yan Chen1, Ning Tan1 and Li-Wen Li1

1Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

2Department of Cardiology, Guangdong General Hospital Zhuhai Hospital (Zhuhai Golden Bay Center Hospital), Zhuhai, Guangdong, China

3The George Institute for Global Health, Sydney, Australia

4National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Department of Biostatistics, School of Public Health and Tropical Medicine Southern Medical University, Guangzhou, Guangdong, China

*These authors contributed equally to this work

Correspondence to:

Li-Wen Li, email: [email protected]

Ning Tan, email: [email protected]

Keywords: heart failure; acute kidney injury; hydration; contrast; coronary angiography

Received: May 30, 2017     Accepted: March 10, 2018     Published: May 04, 2018


We investigated the relationship between weight-adjusted hydration volumes and the risk of developing contrast-induced acute kidney injury (CI-AKI) and worsening heart failure (WHF) and explored the relative safety of optimal hydration volumes in patients with advanced congestive heart failure (CHF) undergoing coronary angiography (CAG) or percutaneous coronary intervention. We included 551 patients with advanced CHF (New York Heart Association class > 2 or history of pulmonary edema) undergoing CAG (follow-up period 2.62 ± 0.9 years). There was a significant association between hydration volume-to-weight ratio (HV/W) (quintile Q1, Q2, Q3, Q4, and Q5) and the incidence of CI-AKI (3.7%, 14.6%, 14.3%, 21.1%, and 31.5%, respectively) and WHF (3.6%, 5.4%, 8.3%, 13.6%, and 19.1%, respectively) (all P-trend < 0.001). Receiver operating curve analysis indicated that HV/W = 15 mL/kg and the mean HV/W (60.87% sensitivity and 64.96% specificity) were fair discriminators for CI-AKI (C-statistic 0.696). HV/W >15 mL/kg independently predicted CI-AKI (adjusted odds ratio [OR] 2.33; P = 0.016) and WHF (adjusted OR 2.13; P = 0.018). Moreover, both CI-AKI and WHF were independently associated with increased long-term mortality. Thus, for high-risk patients with advanced CHF undergoing CAG, HV/W > 15 mL/kg might be associated with an increased risk of developing CI-AKI and WHF. The potential benefits of a personalized limitation of hydration volume need further evaluation.

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