Research Papers:

Human papilloma virus: global research architecture assessed by density-equalizing mapping

Dörthe Brüggmann, Luise Kayser, Jenny Jaque, Matthias Bundschuh, Doris Klingelhöfer _ and David A. Groneberg

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Oncotarget. 2018; 9:21965-21977. https://doi.org/10.18632/oncotarget.25136

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Dörthe Brüggmann1,2, Luise Kayser2, Jenny Jaque1, Matthias Bundschuh2, Doris Klingelhöfer2 and David A. Groneberg2

1Department of Obstetrics and Gynecology, Keck School of Medicine of USC, Los Angeles, CA 90033, USA

2Department of Female Health and Preventive Medicine, Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe-University, Frankfurt 60590, Germany

Correspondence to:

Doris Klingelhöfer, email: [email protected]

Keywords: HPV; human papilloma virus; publication; bibliometry; scientometry

Received: August 16, 2017     Accepted: March 11, 2018     Published: April 24, 2018


Human papilloma virus (HPV) infection is linked to cervical cancer, which represents the world's fourth most common cancer in women. So far, no detailed map of the worldwide HPV research architecture has been constructed. Hence, this study focuses on the chronological development and geographical distribution of the global HPV-specific publications and evaluates citation-based parameters as well as socioeconomic features of the publishing countries.

In total, 29,330 HPV-related publications were identified. The US was the leading country with 12,270 publications. Only high-income-countries were found in the ranking of the fifteen most active countries with Germany, France, and Japan among the top five. Analysis of HPV research activity in relation to the economic strength demonstrated a lead position of Finland and Sweden with an average of 2248.78 and 1924.67 HPV-related publications per GDP in 1000 bn US-$, respectively. The most active upper-middle-income country was Mexico (416.78 HPV-related publications per GDP in 1000 bn US-$). India as lower-middle-income country reached a value of 279.78 HPV-related publications per GDP in 1000 bn US-$. Collaboration analysis pointed to the US as the center of the 4517 international HPV collaborations.

The worldwide HPV-research landscape is dominated by North American and Western European countries. By contrast, a high prevalence of HPV-related cervical cancer is documented for low-income countries. Hence, HPV-related public health interventions and prevention research specifically tailored to these countries needs to be fostered by monetary support and international collaborations.

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