Implantable wireless powered light emitting diode (LED) for near-infrared photoimmunotherapy: device development and experimental assessment in vitro and in vivo
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Kohei Nakajima1, Toshihiro Kimura1,2,4, Hideo Takakura1, Yasuo Yoshikawa3, Atsushi Kameda4, Takayuki Shindo4, Kazuhide Sato5, Hisataka Kobayashi5 and Mikako Ogawa1,6
1Laboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan
2Savior, Inc., Yokohama, Kanagawa, Japan
3Piolax Medical Devices, Inc., Yokohama, Kanagawa, Japan
4B and Plus K.K., Ogawamachi, Saitama, Japan
5Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
6Presto, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
Mikako Ogawa, email: [email protected]
Hisataka Kobayashi, email: [email protected]
Keywords: light emitting diode (LED); wireless power transfer; phototherapy; near-infrared photoimmunotherapy (NIR-PIT)
Received: February 16, 2018 Accepted: March 21, 2018 Published: April 13, 2018
Purpose: The aim of this study was to develop and assess a novel implantable, wireless-powered, light-emitting diode (LED) for near-infrared photoimmunotherapy (NIR-PIT). NIR-PIT is a recently developed cancer therapy that uses NIR light and antibody-photosensitizer conjugates and is able to induce cancer-specific cell death. Due to limited light penetration depth it is currently unable to treat tumors in deep tissues. Use of implanted LED might potentially overcome this limitation.
Results: The wireless LED system was able to emit NIR light up to a distance of 20 cm from the transmitter coil by using low magnetic fields as compliant with limits for use in humans. Results indicated that the LED system was able to kill tumor cells in vitro and to suppress tumor growth in implanted tumor-bearing mice.
Conclusions: Results indicated that the proposed implantable wireless LED system was able to suppress tumor growth in vivo. These results are encouraging as wireless LED systems such as the one here developed might be a possible solution to treat tumors in deep regions in humans. Further research in this area would be important.
Materials and Methods: An implantable LED system was developed. It consisted of a LED capsule including two LED sources and a receiver coil coupled with an external coil and power source. Wireless power transmission was guaranteed by using electromagnetic induction. The system was tested in vitro by using EGFR-expressing cells and HER2-expressing cells. The system was also tested in vivo in tumor-bearing mice.
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