Oncotarget

Research Papers:

Total lesion glycolysis on FDG-PET/CT before salvage surgery predicts survival in laryngeal or pharyngeal cancer

Hidenori Suzuki _, Tsuneo Tamaki, Masami Nishio, Yusuke Nakata, Nobuhiro Hanai, Daisuke Nishikawa, Yusuke Koide and Yasuhisa Hasegawa

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Oncotarget. 2018; 9:19115-19122. https://doi.org/10.18632/oncotarget.24914

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Abstract

Hidenori Suzuki1, Tsuneo Tamaki2, Masami Nishio3, Yusuke Nakata4, Nobuhiro Hanai1, Daisuke Nishikawa1, Yusuke Koide1 and Yasuhisa Hasegawa1

1Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan

2Department of East Nagoya Positron Emission Tomography Imaging Center, Nagoya, Japan

3Department of Radiology, Nagoya Positron Emission Tomography Imaging Center, Nagoya, Japan

4Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan

Correspondence to:

Hidenori Suzuki, email: hi.suzuki@aichi-cc.jp

Keywords: laryngeal and pharyngeal squamous cell carcinoma; 18F-FDG-PET/CT; total lesion glycolysis; overall survival; lung metastasis

Received: August 03, 2017     Accepted: March 07, 2018     Published: April 10, 2018

ABSTRACT

We investigated whether 18F-fluorodeoxyglucose uptake parameters using positron emission tomography combined with computed tomography predicts several survival outcomes, including lung metastasis-free survival, in patients with laryngeal or pharyngeal cancer who underwent salvage surgery. The maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were calculated as 18F-fluorodeoxyglucose uptake parameters in 51 patients with laryngeal or pharyngeal cancer before salvage surgery. In univariate analysis, the maximum standardized uptake value ≥ 22.8, metabolic tumor volume ≥ 2.4, and total lesion glycolysis ≥ 5.4 were significantly correlated with shorter overall survival. In multivariate analysis with adjustment for clinical stage, patients with total lesion glycolysis ≥ 5.4 exhibited significantly shorter overall survival. Furthermore, total lesion glycolysis ≥ 5.4 was significantly correlated with shorter disease-specific survival, distant metastasis-free survival, and lung metastasis-free survival in univariate analysis. In conclusion, total lesion glycolysis predicts the survival outcomes including lung metastasis in patients with laryngeal or pharyngeal cancer who underwent salvage surgery.


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