Research Papers:

Influence of aprepitant and localization of the patch on fentanyl exposure in patients with cancer using transdermal fentanyl

Evelien J.M. Kuip _, Wendy H. Oldenmenger, Martine F. Visser-Thijs, Peter de Bruijn, Esther Oomen-de Hoop, Ron H.J. Mathijssen, Carin C.D. Van der Rijt and Stijn W. Koolen

PDF  |  HTML  |  How to cite

Oncotarget. 2018; 9:18269-18276. https://doi.org/10.18632/oncotarget.24812

Metrics: PDF 1507 views  |   HTML 2153 views  |   ?  


Evelien J.M. Kuip1,2,3, Wendy H. Oldenmenger1, Martine F. Visser-Thijs1, Peter de Bruijn1, Esther Oomen-de Hoop1, Ron H.J. Mathijssen1, Carin C.D. Van der Rijt1 and Stijn W. Koolen1

1Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

2Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands

3Department of Anesthesiology, Pain and Palliative Care, Radboud University Medical Center, Nijmegen, The Netherlands

Correspondence to:

Evelien J.M. Kuip, email: [email protected]

Keywords: fentanyl; aprepitant; pharmacokinetics; cancer

Received: November 13, 2017     Accepted: February 25, 2018     Published: April 06, 2018


Background and Objectives: The cutaneous fentanyl patch is widely used to treat continuous pain in patients with cancer. Its use is hampered by a high inter- and intrapatient pharmacokinetic variability. Factors that influence this pharmacokinetic variability are largely unclear. The aim of these studies was to test if common patient variables, i) the use of the moderate CYP3A4 inhibitor aprepitant and ii) the localization of the fentanyl patch (upper arm versus thorax) influence systemic exposure to fentanyl in patients with cancer using a transdermal fentanyl patch.

Results: The AUC0–6 h of fentanyl was 7.1% (95% CI: –28% to +19%) lower if patients concurrently used aprepitant, compared to the period when patients used fentanyl only. The AUC0–4 h of fentanyl was 7.4% (95% CI: –22% to +49%) higher when the cutaneous fentanyl patch was applied to the upper arm compared to application at the thorax.

Conclusions: Neither the concurrent use of aprepitant, nor the localization of the fentanyl patch showed a statistically significant influence on fentanyl pharmacokinetics.

Methods: We performed two prospective cross-over pharmacokinetic intervention studies. Both studies had two eight-day study periods. At day 8 of each study period blood samples were collected for pharmacokinetic analysis. In each study 14 evaluable patients were included.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 24812