Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1

Laura Ciarlo; Rosa Vona; Valeria Manganelli; Lucrezia Gambardella; Carla Raggi; Matteo Marconi; Walter Malorni; Maurizio Sorice; Tina Garofalo; Paola Matarrese

doi:10.18632/oncotarget.24792

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Research Papers:

Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1

Laura Ciarlo, Rosa Vona, Valeria Manganelli, Lucrezia Gambardella, Carla Raggi, Matteo Marconi, Walter Malorni, Maurizio Sorice, Tina Garofalo and Paola Matarrese _

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Oncotarget. 2018; 9:18869-18884. https://doi.org/10.18632/oncotarget.24792

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Abstract

Laura Ciarlo1,*, Rosa Vona1,*, Valeria Manganelli2,*, Lucrezia Gambardella1, Carla Raggi3, Matteo Marconi1, Walter Malorni1, Maurizio Sorice2, Tina Garofalo2,# and Paola Matarrese1,4,#

1Oncology Unit, Center for Gender-Specific Medicine, Istituto Superiore di Sanità, Rome, Italy

2Department of Experimental Medicine, Sapienza University, Rome, Italy

3Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy

4Center of Metabolomics, Rome, Italy

*These authors contributed equally to this work

#These authors to be considered as Senior Authors

Correspondence to:

Paola Matarrese, email: [email protected]

Keywords: lipid rafts; mitochondria; fusion; apoptosis; reactive oxygen species

Received: July 22, 2017 Accepted: February 27, 2018 Published: April 10, 2018

ABSTRACT

The regulation of the mitochondrial dynamics and the balance between fusion and fission processes are crucial for the health and fate of the cell. Mitochondrial fusion and fission machinery is controlled by key proteins such as mitofusins, OPA-1 and several further molecules. In the present work we investigated the implication of lipid rafts in mitochondrial fusion induced by Mdivi-1. Our results underscore the possible implication of lipid “rafts” in mitochondrial morphogenetic changes and their homeostasis.

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Research Papers:

Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1

Abstract