Oncotarget

Research Papers:

Incidence and risk factors for venous thromboembolism in patients with pretreated advanced pancreatic carcinoma

Shunsuke Kondo _, Mitsuhito Sasaki, Hiroko Hosoi, Yasunari Sakamoto, Chigusa Morizane, Hideki Ueno and Takuji Okusaka

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Oncotarget. 2018; 9:16883-16890. https://doi.org/10.18632/oncotarget.24721

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Abstract

Shunsuke Kondo1,2, Mitsuhito Sasaki1,3, Hiroko Hosoi1, Yasunari Sakamoto1, Chigusa Morizane1, Hideki Ueno1 and Takuji Okusaka1

1Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan

2Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan

3Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Chiba, Japan

Correspondence to:

Shunsuke Kondo, email: shkondo@ncc.go.jp

Keywords: fibrin degradation product; incidence; pancreatic carcinoma; survival; venous thromboembolism

Received: November 22, 2017    Accepted: February 28, 2018    Published: March 30, 2018

ABSTRACT

Patients with pancreatic carcinoma are at an increased risk of venous thromboembolism (VTE), which is a major cause of morbidity and mortality in various types of cancer. The aim of this study was to determine the incidence and clinical significance of VTE in patients with pancreatic carcinoma, and to identify biomarkers for the detection of VTE in these patients. The eligibility criteria were chemo-naïve patients with primary pancreatic carcinoma, an Eastern Cooperative Oncology Group performance status of 0–2, and adequate organ function. All patients were screened for VTE using compression ultrasonography and dynamic computed tomography. The primary endpoint was the incidence of VTE, which we hypothesized would be between 10.0–20.0% for symptomatic and asymptomatic patients combined. Associations between clinical presentation and VTE were evaluated. VTE-associated markers were also investigated for their role in predicting prognosis. In total, 103 patients met the eligibility criteria. The overall cumulative incidence rate of VTE in patients with previously untreated pancreatic carcinoma was 16.5%. VTE occurrence was strongly associated with elevated serum D-dimer, fibrin degradation product, thrombin/antithrombin III complex, and prothrombin fragment 1 + 2 levels. The median overall survival time of VTE-positive and VTE-negative patients was 427 and 515 days, respectively. Approximately one-sixth of patients with advanced pancreatic carcinoma experienced VTE, although most were asymptomatic. Measurement of serum D-dimer, fibrin degradation product, thrombin/antithrombin III complex, and prothrombin fragment 1 + 2 levels may be useful for the early detection of VTE in patients with advanced pancreatic carcinoma.


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