Oncotarget

Clinical Research Papers:

Relationship between hospital volume and short-term outcomes: a nationwide population-based study including 75,280 rectal cancer surgical procedures

Salvatore Pucciarelli _, Manuel Zorzi, Nicola Gennaro, Francesco Marchegiani, Andrea Barina, Massimo Rugge, Matteo Zuin, Alessandro Perin, Isacco Maretto, Francesca Bergamo, Caterina Boso, Emanuele Damiano Luca Urso, Patrick Frambach and Maria Chiara Corti

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Oncotarget. 2018; 9:17149-17159. https://doi.org/10.18632/oncotarget.24699

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Abstract

Salvatore Pucciarelli1, Manuel Zorzi2, Nicola Gennaro3, Francesco Marchegiani1, Andrea Barina1, Massimo Rugge2,4, Matteo Zuin1, Alessandro Perin1, Isacco Maretto1, Francesca Bergamo5, Caterina Boso6, Emanuele Damiano Luca Urso1, Patrick Frambach1 and Maria Chiara Corti3

1Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy

2Regional Health Service, Veneto Tumor Registry, Veneto Region, Padua, Italy

3Regional Health Service, Epidemiology Unit, Veneto Region, Padua, Italy

4Department of Medicine DIMED, Pathology and Cytopathology Unit, University of Padua, Padua, Italy

5Medical Oncology 1, Veneto Institute of Oncology IOV – IRCCS, Padua, Italy

6Radiation Oncology, Veneto Institute of Oncology IOV – IRCCS, Padua, Italy

Correspondence to:

Salvatore Pucciarelli, email: puc@unipd.it

Keywords: rectal cancer; hospital volume; volume-outcome relationship; short-term outcomes; population study

Abbreviations: APR: abdominoperineal resection; CI: confidence interval; HV: hospital volume; LOS: length of stay; OR: odds ratio

Received: July 12, 2017     Accepted: February 28, 2018     Published: March 30, 2018

ABSTRACT

There is growing interest on the potential relationship between hospital volume (HV) and outcomes as it might justify the centralization of care for rectal cancer surgery.

From the National Italian Hospital Discharge Dataset, data on 75,280 rectal cancer patients who underwent elective major surgery between 2002 and 2014 were retrieved and analyzed. HV was grouped into tertiles: low-volume performed 1-12, while high-volume hospitals performed 33+ procedures/year. The impact of HV on in-hospital mortality, abdominoperineal resection (APR), 30-day readmission, and length of stay (LOS) was assessed. Risk factors were calculated using multivariate logistic regression.

The proportion of procedures performed in low-volume hospitals decreased by 6.7 percent (p<0.001). The rate of in-hospital mortality, APR and 30-day readmission was 1.3%, 16.3%, and 7.2%, respectively, and the median LOS was 13 days. The adjusted risk of in-hospital mortality (OR = 1.49, 95% CI = 1.25-1.78), APR (OR 1.10, 95%CI 1.02-1.19), 30-day readmission (OR 1.49, 95%CI 1.38-1.61), and prolonged LOS (OR 2.29, 95%CI 2.05-2.55) were greater for low-volume hospitals than for high-volume hospitals.

This study shows an independent impact of HV procedures on all short-term outcome measures, justifying a policy of centralization for rectal cancer surgery, a process which is underway.


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