Oncotarget

Research Papers:

Total body irradiation and iron chelation treatment are associated with pancreatic injury following pediatric hematopoietic stem cell transplantation

Natalia Maximova _, Massimo Gregori, Roberto Simeone, Aurelio Sonzogni, Davide Zanon, Giulia Boz and Lorenzo D’Antiga

PDF  |  HTML  |  How to cite

Oncotarget. 2018; 9:19543-19554. https://doi.org/10.18632/oncotarget.24646

Metrics: PDF 1730 views  |   HTML 2113 views  |   ?  


Abstract

Natalia Maximova1, Massimo Gregori2, Roberto Simeone3, Aurelio Sonzogni4, Davide Zanon5, Giulia Boz6 and Lorenzo D’Antiga7

1Bone Marrow Transplant Unit, Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy

2Department of Pediatric Radiology, Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy

3Department of Transfusion Medicine, Trieste University Hospital, Trieste, Italy

4Department of Pathology, Hospital Papa Giovanni XXIII, Bergamo, Italy

5Pharmacy, Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy

6Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy

7Pediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, Bergamo, Italy

Correspondence to:

Natalia Maximova, email: [email protected]

Keywords: allogeneic HSCT; pediatric patients; acute pancreatic iron overload; exocrine pancreatic dysfunction; pancreatic shrinkage

Received: October 31, 2017    Accepted: February 26, 2018    Published: April 13, 2018

ABSTRACT

Whereas many studies have addressed the risk of organ dysfunction following hematopoietic stem cell transplantation (HSCT), little is known about pancreatic susceptibility in this setting. We aimed to investigate the effect of iron overload (IO) and total body irradiation (TBI) on pancreatic function of children undergoing HSCT.

We retrospectively evaluated children admitted between 2012-2016 fulfilling the following criteria: normal pancreatic iron concentration (PIC), regular pancreatic function before HSCT, availability of abdominal magnetic resonance imaging with gradient-recalled-echo sequences and a full set of biochemical markers of IO and pancreatic function performed before HSCT and at discharge. We divided the patients according to the use of TBI or myeloablative chemotherapy (MCHT) in the conditioning regimen. All patients with severe IO or moderate IO with a high risk of engraftment delay or transplantation-related complications underwent chelation therapy with deferoxamine (DFO) from the first day of conditioning to discharge.

63 patients had a HSCT in the study period, 13 did not fulfill the inclusion criteria; 50 (25 in each group) are included in the analysis, and did not show differences at baseline evaluation. At follow up testing the TBI group showed a significantly higher PIC (107,8±100,3 μmol/g vs 28,4±37,9 in MCHT group, p<0,0001). In the TBI group the patients who had DFO treatment had higher PIC (223,2±48,8 μmol/g vs 55,7±10,5 without DFO treatment, p<0,0001), and all patients having PIC >100 μmol/g at follow up had DFO-based chelation therapy, versus 26% of those with lower PIC (p<0,0001). The number of patients presenting exocrine pancreatic dysfunctions one month after transplantation was significantly higher in the TBI group (48% vs 4%; p<0.0001). The mean pancreatic volume reduction was significantly greater in the TBI group (39,1% vs 0,9% in the MCHT group; p<0,05), and was significantly worse on those who received DFO therapy.

Based on our data, we suggest that TBI is detrimental for pancreatic functions, and speculate that DFO may contribute to the rapid pancreatic IO observed in these patients.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 24646