Cancer stem cells of hepatocellular carcinoma

Kewei Wang _ and Dianjun Sun

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Oncotarget. 2018; 9:23306-23314. https://doi.org/10.18632/oncotarget.24623

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Kewei Wang1,2,3,4 and Dianjun Sun2,3,4

1Institute of Cell Biotechnology, China and Russia Medical Research Center, Harbin Medical University, Harbin, China

2Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin, China

3Key Laboratory of Etiology and Epidemiology (23618504), National Health and Family Planning Commission of the People’s Republic of China, Harbin, China

4Harbin Medical University, Harbin, China

Correspondence to:

Kewei Wang, email: [email protected]

Keywords: hepatocellular carcinoma; cancer stem cells; hepatic oval cells; apoptosis; CAR T-cells

Received: June 13, 2017     Accepted: February 12, 2018     Published: May 01, 2018


Hepatocellular carcinoma is a malignant tumor arising from hepatocytes. The hepatocellular carcinoma is dictated by a subset of cells with stem cell-like features. These cells are apoptosis-resistant and have particular biomarkers, which serve as seeds in different stages of tumorigenesis including initiation, progression, metastasis, and relapse of hepatocellular carcinoma. Signaling pathways of cancer stem cells are novel targets for the radical intervention of hepatocellular carcinoma.

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