Liquid biopsy provides new insights into gastric cancer

Camila Tavares Uchôa Guimarães _, Nina Nayara Ferreira Martins, Kelly Cristina da Silva Oliveira, Caroline Martins Almeida, Thayanne Macedo Pinheiro, Carolina Oliveira Gigek, Sandro Roberto de Araújo Cavallero, Paulo Pimentel Assumpção, Marília Arruda Cardoso Smith, Rommel Rodríguez Burbano and Danielle Queiroz Calcagno

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Oncotarget. 2018; 9:15144-15156. https://doi.org/10.18632/oncotarget.24540

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Camila Tavares Uchôa Guimarães1,*, Nina Nayara Ferreira Martins2,*, Kelly Cristina da Silva Oliveira2, Caroline Martins Almeida1, Thayanne Macedo Pinheiro2, Carolina Oliveira Gigek3,4, Sandro Roberto de Araújo Cavallero2, Paulo Pimentel Assumpção2, Marília Arruda Cardoso Smith3, Rommel Rodríguez Burbano2,5 and Danielle Queiroz Calcagno1,2

1Residência Multiprofissional em Oncologia, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, PA, Brazil

2Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, Brazil

3Disciplina de Genética, Universidade Federal de São Paulo, São Paulo, SP, Brazil

4Disciplina de Gastroenterologia Cirurgica, Universidade Federal de São Paulo, São Paulo, SP, Brazil

5Laboratório de Biologia Molecular, Hospital Ophir Loyola, Belém, PA, Brazil

*These authors contributed equally to this work

Correspondence to:

Danielle Queiroz Calcagno, email: [email protected]

Keywords: circulating tumor cells; circulating tumor DNA; circulating microRNAs; circulating long non-coding RNAs; precision medicine

Received: July 26, 2017     Accepted: December 01, 2017     Epub: February 21, 2018     Published: March 13, 2018


Liquid biopsies have great promise for precision medicine as they provide information about primary and metastatic tumors via a minimally invasive method. In gastric cancer patients, a large number of blood-based biomarkers have been reported for their potential role in clinical practice for screening, early diagnosis, prognostic evaluation, recurrence monitoring and therapeutic efficiency follow-up. This current review focuses on blood liquid biopsies' role and their clinical implications in gastric cancer patients, with an emphasis on circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) and circulating non-coding RNAs (ncRNAs). We also provide a brief discussion of the potential and limitations of liquid biopsies use and their future use in the routine clinical care of gastric cancer.

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