Clinicopathological and prognostic significance of Twist overexpression in NSCLC

Meng Li _, Xing Zhang, Xiaoqing Xu, Jiubin Wu, Kaiwen Hu, Xiuwei Guo and Peitong Zhang

PDF  |  HTML  |  Supplementary Files  |  How to cite

Oncotarget. 2018; 9:14642-14651. https://doi.org/10.18632/oncotarget.24489

Metrics: PDF 1068 views  |   HTML 1678 views  |   ?  


Meng Li1,2,*, Xing Zhang1,2,*, Xiaoqing Xu1,2, Jiubin Wu3, Kaiwen Hu4, Xiuwei Guo1 and Peitong Zhang1

1Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China

2Beijing University of Chinese Medicine, Beijing, China

3Department of Traumatology and Orthopedics, First Affiliated Hospital of Tianjin University of TCM, Tianjin, China

4Department of Oncology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China

*These authors contributed equally to this work

Correspondence to:

Peitong Zhang, email: [email protected]

Keywords: non-small cell lung cancer; Twist; prognosis; meta-analysis

Received: August 29, 2017     Accepted: November 14, 2017     Epub: February 14, 2018     Published: March 06, 2018


Several studies were conducted to explore the prognostic significance of Twist in non-small cell lung cancer (NSCLC), however, contradictory results in different studies were reported. To this end, we presented a systematic review aiming to summarize the prognostic significance of Twist in patients with NSCLC. 5 studies involving a total of 572 patients were identified. The result indicated that high Twist expression was significantly associated with a worse overall survival (OS) (hazard ratio (HR) = 2.19, 95% confidence interval (95% CI) = 1.64–2.94, p < 0.001; I2 = 0.0%, fixed effect), recurrence-free survival (RFS) (HR = 2.476, 95% CI = 1.728–3.547, p < 0.001; I2 = 0.0%, fixed effect) and lymph node or other metastasis (odds rate (OR) = 0.419, 95% CI = 0.259–0.679, P < 0.001, fixed effect). Subgroup analysis revealed that the expression of Twist in Chinese patients might be more closely associated with the prognosis of NSCLC than in American patients. Overall, these results indicated that Twist over-expression in patients with NSCLC might be related to poor prognosis and serves as an unfavorable predictor of poor clinicopathological prognosis factor.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 24489