Meta-Analysis:
Clinicopathological and prognostic significance of Twist overexpression in NSCLC
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Abstract
Meng Li1,2,*, Xing Zhang1,2,*, Xiaoqing Xu1,2, Jiubin Wu3, Kaiwen Hu4, Xiuwei Guo1 and Peitong Zhang1
1Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
2Beijing University of Chinese Medicine, Beijing, China
3Department of Traumatology and Orthopedics, First Affiliated Hospital of Tianjin University of TCM, Tianjin, China
4Department of Oncology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China
*These authors contributed equally to this work
Correspondence to:
Peitong Zhang, email: [email protected]
Keywords: non-small cell lung cancer; Twist; prognosis; meta-analysis
Received: August 29, 2017 Accepted: November 14, 2017 Epub: February 14, 2018 Published: March 06, 2018
ABSTRACT
Several studies were conducted to explore the prognostic significance of Twist in non-small cell lung cancer (NSCLC), however, contradictory results in different studies were reported. To this end, we presented a systematic review aiming to summarize the prognostic significance of Twist in patients with NSCLC. 5 studies involving a total of 572 patients were identified. The result indicated that high Twist expression was significantly associated with a worse overall survival (OS) (hazard ratio (HR) = 2.19, 95% confidence interval (95% CI) = 1.64–2.94, p < 0.001; I2 = 0.0%, fixed effect), recurrence-free survival (RFS) (HR = 2.476, 95% CI = 1.728–3.547, p < 0.001; I2 = 0.0%, fixed effect) and lymph node or other metastasis (odds rate (OR) = 0.419, 95% CI = 0.259–0.679, P < 0.001, fixed effect). Subgroup analysis revealed that the expression of Twist in Chinese patients might be more closely associated with the prognosis of NSCLC than in American patients. Overall, these results indicated that Twist over-expression in patients with NSCLC might be related to poor prognosis and serves as an unfavorable predictor of poor clinicopathological prognosis factor.
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