Research Papers:

Association between angiotensin II receptor type 1 A1166C polymorphism and chronic kidney disease

Hsien-Feng Chang, Po-Jen Hsiao, Yu-Juei Hsu, Fu-Huang Lin, Chin Lin, Wen Su, Hsiang-Cheng Chen and Sui-Lung Su _

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Oncotarget. 2018; 9:14444-14455. https://doi.org/10.18632/oncotarget.24469

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Hsien-Feng Chang1, Po-Jen Hsiao2,3,4, Yu-Juei Hsu2, Fu-Huang Lin1, Chin Lin1, Wen Su5, Hsiang-Cheng Chen6,* and Sui-Lung Su1,*

1School of Public Health, National Defense Medical Center, Taiwan, ROC

2Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taiwan, ROC

3Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taiwan, ROC

4Big Data Research Center, Fu-Jen Catholic University, Taiwan, ROC

5Department of Nursing, Tri-Service General Hospital, Taiwan, ROC

6Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taiwan, ROC

*These authors have contributed equally to this work

Correspondence to:

Sui-Lung Su, email: [email protected]

Hsiang-Cheng Chen, email: [email protected]

Keywords: angiotensin II receptor type 1; AGTR1 A1166C; chronic kidney disease; meta-analysis; gene-environment interaction

Received: June 08, 2017    Accepted: February 03, 2018    Epub: February 12, 2018    Published: March 06, 2018


Studies of the association between angiotensin II receptor type 1 A1166C (AGTR1 A1166C) polymorphism and chronic kidney disease (CKD) risk have yielded conflicting results. We conducted a combined case-control study and meta-analysis to better define this association. The case-control study included 634 end-stage renal disease (ESRD) patients and 739 healthy controls. AGTR1 A1166C genotype was determined using polymerase chain reaction and iPLEX Gold SNP genotyping methods. The meta-analysis included 24 studies found in the PubMed and Cochrane Library databases. Together, the case-control study and meta-analysis included 36 populations (7,918 cases and 6,905 controls). We found no association between the C allele and ESRD (case-control study: OR: 1.02, 95% CI: 0.77–1.37; meta-analysis: OR: 1.07; 95% CI: 0.97–1.18). Co-dominant, dominant, and recessive model results were also not significant. No known environmental factors moderated the effect of AGTR1 A1166C on CKD in our gene-environment interaction analysis. Sensitivity analysis showed an AGTR1 A1166C-CKD association in Indian populations (OR: 1.46, 95% CI: 1.26–1.69), but not in East Asian or Caucasian populations. Additional South Asian studies will be required to confirm the potential role of this polymorphism in CKD.

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