Prominent role of histone lysine demethylases in cancer epigenetics and therapy
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Avilala Janardhan1,2, Chandrasekhar Kathera2, Amrutha Darsi2, Wajid Ali2, Lingfeng He2, Yanhua Yang1, Libo Luo1 and Zhigang Guo2
1The No. 7 People’s Hospital of Changzhou, Changzhou, China
2Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China
Libo Luo, email: email@example.com
Zhigang Guo, email: firstname.lastname@example.org
Keywords: epigenetics; histone modifications; protein methylation; lysine specific demethylases; therapeutics
Received: November 11, 2017 Accepted: December 04, 2017 Epub: January 25, 2018 Published: September 28, 2018
Protein methylation has an important role in the regulation of chromatin, gene expression and regulation. The protein methyl transferases are genetically altered in various human cancers. The enzymes that remove histone methylation have led to increased awareness of protein interactions as potential drug targets. Specifically, Lysine Specific Demethylases (LSD) removes methylated histone H3 lysine 4 (H3K4) and H3 lysine 9 (H3K9) through formaldehyde-generating oxidation. It has been reported that LSD1 and its downstream targets are involved in tumor-cell growth and metastasis. Functional studies of LSD1 indicate that it regulates activation and inhibition of gene transcription in the nucleus. Here we made a discussion about the summary of histone lysine demethylase and their functions in various human cancers.
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