Research Papers:

Trends in the prevalence of congenital hydrocephalus in 14 cities in Liaoning province, China from 2006 to 2015 in a population-based birth defect registry from the Liaoning Women and Children's Health Hospital

Yan-Hong Huang _, Qi-Jun Wu, Yan-Ling Chen, Cheng-Zhi Jiang, Ting-Ting Gong, Jing Li, Li-Li Li and Chen Zhou

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Oncotarget. 2018; 9:14472-14480. https://doi.org/10.18632/oncotarget.24239

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Yan-Hong Huang1, Qi-Jun Wu2, Yan-Ling Chen3, Cheng-Zhi Jiang4, Ting-Ting Gong5, Jing Li1, Li-Li Li6 and Chen Zhou7

1Department of Science and Education, Shenyang Maternity and Child Health Hospital, Shenyang, China

2Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China

3Liaoning Women and Children’s Health Hospital, Shenyang, China

4School of Environmental and Chemical Engineering, Shenyang Ligong University, Shenyang, China

5Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China

6Department of Children's Health Prevention, Shenyang Maternity and Child Health Hospital, Shenyang, China

7Department of Information Statistics, Shenyang Maternity and Child Health Hospital, Shenyang, China

Correspondence to:

Yan-Hong Huang, email: [email protected]

Keywords: congenital hydrocephalus; Liaoning province; poisson regression; prevalence; time trend

Received: July 11, 2017     Accepted: December 05, 2017     Epub: January 13, 2018     Published: March 06, 2018


The aim of this study was to assess the prevalence and trends of congenital hydrocephalus (CH) using a large population-based sample with cases retrieved from the Liaoning Birth Defects Registry, which included 14 cities, over a 10-year period. CH prevalence, percent change, average change, and contribution rates of each city were calculated. Statistical analysis was performed using a Poisson regression model. There was a total of 3008 CH cases among 3,248,954 live births during the observational period (9.26 cases/10,000 live births). On average, the prevalence of CH had significantly decreased by 11.84% each year (P < 0.01). The three leading cities with the highest prevalence of CH were Chaoyang (13.73/10,000), Huludao (13.18/10,000), and Fuxin (12.71/10,000), while Yingkou (6.06/10,000), Dalian (6.27/10,000), and Anshan (6.56/10,000) had the lowest prevalence. Notably, significantly decreasing trends were observed in 10 (71.4%) of these 14 cities. In addition, the cities of Fushun, Shenyang, and Dalian had contributed to more than one-third of the decreasing trend in Liaoning province. In conclusion, this study provides evidence of the decreasing prevalence of CH over a 10-year period (2006–2015) in Liaoning province. Preventative efforts should be strengthened to further reduce the risk of CH in these high prevalence areas.

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