Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis
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Chong Guo1,*, Li Wen2,*, Ju-Kun Song3,*, Weng-Jing Zeng4, Chao Dan5, Yu-Ming Niu1,6 and Ming Shen7
1Center for Evidence-Based Medicine and Clinical Research, Department of Gynecology and Obstetrics, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
2Department of Dermatology, Suizhou Central Hospital, Hubei University of Medicine, Shiyan 442000, China
3Department of Oral and Maxillary Surgery, Guizhou Provincial People's Hospital, Guiyang 550002, China
4Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
5Department of Urinary Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
6Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
7Jiangsu Key Laboratory of Oral Diseases, Department of Dental Implant, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China
*These authors contributed equally to this work
Yu-Ming Niu, email: [email protected]
Ming Shen, email: [email protected]
Keywords: interleukin-10; polymorphism; cervical cancer; meta-analysis
Received: July 12, 2017 Accepted: December 04, 2017 Published: January 12, 2018
Previous studies have suggested that interleukin-10 (IL-10) polymorphisms may be associated with an increased risk of developing cervical cancer. However, the published results on this subject matter are controversial. The aim of this study was to conduct a meta-analysis of published reports to more precisely investigate the relationship between IL-10 polymorphisms and cervical cancer risk. Five online databases (PubMed, Embase, Web of SCI, CNKI and Wanfang) were searched, and seventeen articles with sufficient quantitative information were included in our meta-analysis. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the association between IL-10 polymorphisms and cervical cancer risk. Publication bias, sensitivity and cumulative analyses were also performed to support our findings. Overall, there was a significant association between the IL-10 -1082A > G polymorphism and cervical cancer risk observed in the total population (G vs. A: OR = 1.60, 95% CI = 1.12–2.29, P = 0.01, I2 = 92.3%; AG vs. AA: OR = 1.34, 95% CI = 1.04-1.74, P = 0.03, I2 = 65.9%; AG + GG vs. AA: OR = 1.58, 95% CI = 1.11–2.25, P = 0.01, I2 = 84.4%), and the same results were obtained in the subgroup analysis. Moreover, the IL-10 -819 T > C polymorphism exhibited a significant, protective effect against cervical cancer. In summary, our meta-analysis suggests that IL-10 polymorphisms may play a variety of roles in regard to cervical cancer risk, especially in Asians.
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