Oncotarget

Meta-Analysis:

Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis

Chong Guo _, Li Wen, Ju-Kun Song, Weng-Jing Zeng, Chao Dan, Yu-Ming Niu and Ming Shen

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Oncotarget. 2018; 9:12365-12375. https://doi.org/10.18632/oncotarget.24193

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Abstract

Chong Guo1,*, Li Wen2,*, Ju-Kun Song3,*, Weng-Jing Zeng4, Chao Dan5, Yu-Ming Niu1,6 and Ming Shen7

1Center for Evidence-Based Medicine and Clinical Research, Department of Gynecology and Obstetrics, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China

2Department of Dermatology, Suizhou Central Hospital, Hubei University of Medicine, Shiyan 442000, China

3Department of Oral and Maxillary Surgery, Guizhou Provincial People's Hospital, Guiyang 550002, China

4Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China

5Department of Urinary Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China

6Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China

7Jiangsu Key Laboratory of Oral Diseases, Department of Dental Implant, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China

*These authors contributed equally to this work

Correspondence to:

Yu-Ming Niu, email: niuyuming@yeah.net

Ming Shen, email: mingshen85@yahoo.com

Keywords: interleukin-10; polymorphism; cervical cancer; meta-analysis

Received: July 12, 2017     Accepted: December 04, 2017     Published: January 12, 2018

ABSTRACT

Previous studies have suggested that interleukin-10 (IL-10) polymorphisms may be associated with an increased risk of developing cervical cancer. However, the published results on this subject matter are controversial. The aim of this study was to conduct a meta-analysis of published reports to more precisely investigate the relationship between IL-10 polymorphisms and cervical cancer risk. Five online databases (PubMed, Embase, Web of SCI, CNKI and Wanfang) were searched, and seventeen articles with sufficient quantitative information were included in our meta-analysis. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the association between IL-10 polymorphisms and cervical cancer risk. Publication bias, sensitivity and cumulative analyses were also performed to support our findings. Overall, there was a significant association between the IL-10 -1082A > G polymorphism and cervical cancer risk observed in the total population (G vs. A: OR = 1.60, 95% CI = 1.12–2.29, P = 0.01, I2 = 92.3%; AG vs. AA: OR = 1.34, 95% CI = 1.04-1.74, P = 0.03, I2 = 65.9%; AG + GG vs. AA: OR = 1.58, 95% CI = 1.11–2.25, P = 0.01, I2 = 84.4%), and the same results were obtained in the subgroup analysis. Moreover, the IL-10 -819 T > C polymorphism exhibited a significant, protective effect against cervical cancer. In summary, our meta-analysis suggests that IL-10 polymorphisms may play a variety of roles in regard to cervical cancer risk, especially in Asians.


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