Oncotarget

Research Papers:

MEIS-1 level in unresectable hepatocellular carcinoma can predict the post-treatment outcomes of radiofrequency ablation

Hui Xie _, Haipeng Yu, Shengtao Tian, Xueling Yang, Ximing Wang, Huaming Wang and Zhi Guo

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Oncotarget. 2018; 9:15252-15265. https://doi.org/10.18632/oncotarget.24165

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Abstract

Hui Xie1,2, Haipeng Yu1, Shengtao Tian2, Xueling Yang1, Ximing Wang2, Huaming Wang2 and Zhi Guo1

1Department of Interventional Therapy, Tianjin Medical University Cancer Institute & Hospital, National Clinical Cancer Research Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300070, PR China

2Department of interventional therapy, 302 Hospital of People's Liberation Army, Beijing 100039, PR China

Correspondence to:

Zhi Guo, email: gztjzlyy@163.com

Huaming Wang, email: wanghm302@163.com

Keywords: RFA; MEIS-1; unresectable HCC; prognosis

Received: August 29, 2017     Accepted: December 01, 2017     Epub: January 11, 2018     Published: March 16, 2018

ABSTRACT

Radiofrequency ablation (RFA) is a local-ablative therapy for unresectable hepatocellular carcinoma (HCC). At present, there is no predictive marker for RFA treatment outcomes. This work aimed to valuate myeloid ecotropic viral integration site 1 (MEIS-1) in predicting post-RFA treatment outcomes of unresectable HCC patients. The time to progression (TTP) and overall survival (OS) of 81 HCC patients who received RFA treatment were measured. The protein level of MEIS-1 in tumor specimens was measured by western blot. The role of MEIS-1 in RFA-treating HCC in vivo growth nude mouse model was examined via PET/CT imaging. Higher level of MEIS-1 in tumor tissue is associated with better RFA treatment outcomes. The median TTP was 9.0 (95% confidence interval [CI]: 6.8–11.3) months in patients with high MEIS-1 expression (n = 43) versus 6.0 (95% CI: 4.6–7.4) months in patients with low MEIS-1 expression (n = 38). Moreover, in rodent HCC model we found overexpression of MEIS-1 enhanced the anti-tumor effect of RFA treatment. We conclude that high level of MEIS-1 expression predicts better RFA treatment outcome in HCC.


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