Research Papers:
P75 neurotrophin receptor activates epidermal stem cell differentiation via ERK JNK and AKT pathways
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Xia Li1,2,*, Gaosong Yang3,*, Yongqian Cao1, Jincun Yang2 and Yibing Wang1
1Department of Burns and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China
2Department of Burns and Plastic Surgery, Weihai Municipal Hospital, Weihai, Shandong, China
3Department of Burns and Plastic Surgery, The First Hospital of Shijiazhuang City, Shijiazhuang, Hebei, China
*These authors contributed equally to this work as the co-first author
Correspondence to:
Yibing Wang, email: [email protected]
Keywords: p75NTR; ESCs; differentiation; wound healing
Received: December 15, 2017 Accepted: January 03, 2018 Published: January 09, 2018
ABSTRACT
As reported, p75 neurotrophin receptor (p75NTR) is involved in activation and differentiation of epidermal stem cells (ESCs). However, the possible signaling pathways of p75NTR in ESCs remain unknown. In this study, p75NTRvo ESCs were constructed to identify the role of p75NTR in cell differentiation. Here we found that P75NTR activated and promoted the differentiation of ESCs. Functionally, P75NTR significantly promoted cell proliferation and migration, and inhibited cell apoptosis. Mechanically, P75NTR stimulated the secretion of NGF in ESCs, and activated ERK, JNK and AKT signaling pathway. Finally in-vivo assay demonstrated that P75NTR effectively promoted wound healing in mice model. In conclusion, P75NTR activates differentiation of epidermal stem cells via ERK, JNK and AKT signaling pathways, and promotes the secretion of NGF and wound healing. Thus, P75NTR may favor skin wound healing in the clinical practice.