Oncotarget

Clinical Research Papers:

Prognostic significance of the red blood cell distribution width that maintain at high level following completion of first line therapy in mutiple myeloma patients

Zhouxiang Jin, Shujuan Zhou, Haige Ye, Songfu Jiang, Kang Yu _ and Yang Ji

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Oncotarget. 2018; 9:10118-10127. https://doi.org/10.18632/oncotarget.24076

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Abstract

Yongyong Ma1,*, Zhouxiang Jin2,*, Shujuan Zhou1, Haige Ye1, Songfu Jiang1 and Kang Yu1

1Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

2Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China

*These authors contributed equally to this work

Correspondence to:

Kang Yu, email: [email protected]

Songfu Jiang, email: [email protected]

Keywords: mutiple myeloma; red blood cell distribution width; first-line therapy; prognosis; survival

Received: October 05, 2017     Accepted: December 05, 2017     Published: January 10, 2018

ABSTRACT

To investigate the prognostic value of the red blood cell distribution width(RDW) recovery from low levels at diagnosis after completion of first line therapy in mutiple myeloma (MM)patients,we enrolled 78 consecutive patients with MM and followed up from 2005 to 2016 in our hospital. The RDW was measured following completion of first-line therapy.The log-rank test, univariate analysis, and Cox regression analysis were used to evaluate the relationship between RDW and survival. We found that patients with an RDW ≥ 15.5% at diagnosis, as well as at completion of first-line therapy, had significantly lower progression-free survival (PFS) and overall survival(OS) rates than those with an RDW < 15.5%(P < 0.05).Patients with RDW that maintained more than 15.5% upon completion of therapy showed a shorter OS (P < 0.05) and PFS (P < 0.05) compared with patients with an RDW that decreased to a lower level.The multivariate analysis showed that RDW ≥ 15.5% after the completion of first-line therapy were an independent prognostic marker of poorer OS (P = 0.044) and PFS (P = 0.034). Therefore,we demonstrated that RDW at diagnosis, as well as at completion of first-line therapy is an independent predictor for mutiple myeloma patients.RDW maintained at high level, irrespective of whether RDW decreased to the cutoff value predicted an unfavorable prognosis in patients with MM.


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