Meta-Analysis:
REG4 expression was a potential marker for carcinogenesis aggressiveness and prognosis of gastric cancer: a meta and bioinformatics analysis
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Hua-Chuan Zheng1, Jing Li2 and Shuang Zhao1
1Department of Experimental Oncology, Shengjing Hospital of China Medical University, Shenyang 110004, China
2Department of Gastroenterology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China
Correspondence to:
Hua-Chuan Zheng, email: [email protected]
Keywords: REG4; gastric cancer; meta analysis; bioinformatics analysis
Received: July 05, 2017 Accepted: December 15, 2017 Published: January 05, 2018
ABSTRACT
REG4 is a potent activator of EGFR/Akt/AP-1 signaling pathway, and a potential marker for mucin-producing carcinoma and neuroendocrine tumors. Here, we performed a systematic meta and bioinformatics analysis through multiple online databases up to March 14, 2017. We found up-regulated REG4 expression in gastric cancer, compared with normal mucosa (p < 0.05). REG4 expression was positively with depth of invasion, lymph node metastasis, TNM staging and dedifferentiation of gastric cancer (p < 0.05). According to bioinformatics databases, REG4 mRNA expression was higher in gastric cancer than normal tissues (p < 0.05), and negatively correlated with histological grading of gastric cancer (p < 0.05). According to Kaplan-Meier plotter, we found that a higher expression of REG4 mRNA was positively correlated with overall and progression-free survival rates of the cancer patients with diffuse-type and N1-3 cancers or undergoing other adjuvant (p < 0.05), but versa for the M1 cancers (p < 0.05). These findings indicated that REG4 expression might be employed as a potential marker to indicate gastric carcinogenesis and subsequent progression, even prognosis.