Case Reports:
Genomic profile of pulmonary follicular dendritic cell sarcoma: a case report and systematic review
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Liyuan Fan1,2, Hongsheng Li2, Minghao Li1,2, Yang Zhang2, Jianping Zhang3 and Baosheng Li2
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China
3Department of Pathology, Qilu Hospital, Shandong University, Jinan, China
Correspondence to:
Baosheng Li, email: [email protected]
Keywords: pulmonary FDCS; copy number variants; high-throughput sequencing; tumor genomic profiling; REL
Received: June 22, 2017 Accepted: December 28, 2017 Published: January 02, 2018
ABSTRACT
Follicular dendritic cell sarcoma (FDCS) is an extremely rare neoplasm which involves both nodal and extranodal sites. The demographics, pathological characteristics and clinical features of this tumor have been reported a lot, but the genomic information is still insufficient.
Here we presented the ninth case of pulmonary FDCS in English publication, whose diagnosis has been revised from “synovial sarcoma” to FDCS. The patient underwent a right pneumonectomy and died of sudden cardiac death within a week after the surgery. Because of the lack of genomic characterization of the tumor, we used the OncoScan®gene chip, which has been optimized for detection of whole genome CNVs. By bioinformatics’ analysis and thoroughly literature review, we found the following suspicious functional genes REL, TET2, CREBBP and CYLD. These genes we found may have important influence on the fate of the neoplasm. Further study for their role of diagnostic and therapeutic targets is needed.