Clinical Research Papers:

Radial EBUS versus CT-guided needle biopsy for evaluation of solitary pulmonary nodules

Wei Wang _, Like Yu, Yuchao Wang, Qian Zhang, Chuanzhen Chi, Ping Zhan and Chunhua Xu

PDF  |  HTML  |  How to cite

Oncotarget. 2018; 9:15122-15131. https://doi.org/10.18632/oncotarget.23952

Metrics: PDF 1422 views  |   HTML 2156 views  |   ?  


Wei Wang1,2,3, Like Yu1,2,3, Yuchao Wang1,2,3, Qian Zhang1,2,3, Chuanzhen Chi1,2,3, Ping Zhan1,2,3 and Chunhua Xu1,2,3

1Endoscopic Center of Nanjing Chest Hospital, Nanjing, 210009, Jiangsu, China

2Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, 210009, China

3Department of Respiratory Medicine, The Affiliated Hospital of Southeast University, Nanjing, Jiangsu 210009, China

Correspondence to:

Chunhua Xu, email: [email protected]

Keywords: solitary pulmonary nodule; endobroncheal ultrasonography guided bronchoscopy; ct guided percutaneous needle biopsy; diagnostic yield; complication

Received: February 08, 2017     Accepted: November 16, 2017     Epub: January 04, 2018     Published: March 13, 2018


Objective: This study is aimed to compare the diagnostic yield, complications and influencing factors between Radial endobroncheal ultrasonography guided bronchoscopy(R-EBUS) and CT-guided needle biopsy (CT-PNB), for evaluation of solitary pulmonary nodules(SPNs).

Matrials and Methods: 160 cases of consecutive patients with SPNs were enrolled and divided into R-EBUS and CT-PNB groups randomly. The diagnostic yield, complications and influencing factors between the two groups were evaluated.

Results: Sensitivity of R-EBUS for malignancy was 73.7% (42/57) and for benign, was 43.5% (10/23), overall diagnostic accuracy was 65% (52/80). In CT-PNB group, overall diagnostic accuracy was 85% (68/80), sensitivity for malignancy was 87.9% (51/58), and for benign was 81.0% (17/21), respectively. Both overall diagnostic yield and incidence of complications in CT-PNB group were higher than those in R-EBUS group (P = 0.006, P = 0.002). In R-EBUS group, the factors affecting diagnostic yield were size (P = 0.027), the distance between SPNs and pleura (P = 0.031) and the location of the probe to lesions (P = 0.009). In CT-PNB group, the distance from the lesions to pleura was correlated with the incidence of pneumothorax (P = 0.001) and pulmonary haemorrhage (P = 0.042). The location of SPNs were adjacent to great vessels was another influencing factor for pulmonary haemorrhage (P = 0.042).

Conclusions: Both R-EBUS and CT-PNB are valuable tools for diagnosis. SPNs located in medial 1/2 of lung field, or were adjacent to great vessels may be fit for R-EBUS. Those SPNs located in lateral 1/2 of lung field, near to pleura or with less vessels around may be more suitable for CT-PNB.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 23952