Coffee consumption and risk of myocardial infarction: a dose-response meta-analysis of observational studies

Long Mo _, Wei Xie, Xiaoqun Pu and Dongsheng Ouyang

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Oncotarget. 2018; 9:21530-21540. https://doi.org/10.18632/oncotarget.23947

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Long Mo1, Wei Xie1, Xiaoqun Pu1 and Dongsheng Ouyang2

1Department of Cardiology, Xiangya Hospital of Centre South University, Changsha, Hunan Province, PR China

2Institute of Genetic Pharmacology, Xiangya School of Medicine, Centre South University, Changsha, Hunan Province, PR China

Correspondence to:

Long Mo, email: [email protected]

Keywords: coffee consumption; myocardial infarction; risk factor; dose-response; meta-analysis

Received: May 30, 2017     Accepted: November 16, 2017     Epub: January 04, 2018     Published: April 20, 2018


Background: Previous epidemiological studies have provided inconsistent conclusions on the effect of coffee consumption in the development of myocardial infarction (MI). The aim of the study was to evaluate the influence of coffee consumption and its potential dose-response patterns on the risk of developing MI.

Materials and Methods: Three databases were searched for evidence of eligible studies. A random-effects model was used to pool the fully adjusted odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Dose-response analysis was performed to show the effect of each cup increased in daily coffee drinking on the risk of MI.

Results: Seventeen studies involving 233,617 participants were included in our study. The association between coffee consumption and risk of MI did not show statistical significance when pooling the outcome data for the coffee consumption categories of 1~2 vs. < 1 cup per day (OR = 1.06, 95% CI: 0.94–1.19) and 2~3 vs. < 1 cup per day (OR = 1.07, 95% CI: 0.94–1.23). Compared with < 1 cup, daily drinking of 3~4 cups and > 4 cups of coffee were significantly associated with the risk of MI, and the pooled ORs (95% CIs) were 1.40 (1.11–1.77) and 1.48 (1.22–1.79), respectively. The dose–response analysis showed a “J–shaped” curve relationship of the risk of MI with coffee consumption.

Conclusions: Daily drinking of more than three cups of coffee was associated with a significantly increased risk of MI. This positive association was only found in men but not in women. The impact of gender on this association should be further evaluated.

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