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Research Papers:

A comparative study of chemotherapy combined with intermittent microwave ablation and chemotherapy in the treatment of oligometastatic non-small cell lung cancer

Linjia Zhu, Shaofei Yuan, Meizhen Liang and Youyi Wu _

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Abstract

Linjia Zhu1, Shaofei Yuan2, Meizhen Liang2 and Youyi Wu2

1Department of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, China

2Department of Oncology, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, China

Correspondence to:

Youyi Wu, email: [email protected]

Keywords: chemotherapy; intermittent; microwave ablation; oligometastatic; non-small cell lung cancer

Received: September 16, 2017     Accepted: December 11, 2017     Published: January 04, 2018

ABSTRACT

Objective: To compare chemotherapy combined with intermittent microwave ablation and chemotherapy alone in the treatment of oligometastatic non-small cell lung cancer.

Results: In the experimental group (n = 34), the total effective rate (CR+PR) was 70.59% vs. 36.36% in the control group (n = 33) (χ2 =7.890, P < 0.01). The score of KPS in the experimental group was higher than that in the control group, indicating obvious difference (P < 0.05). The median PFS in the control group and the experimental group was (3.6 ± 0.2) months and (5.4 ± 0.1) months (χ2 = 42.731, P < 0.01). There was statistical difference that the incidence of pneumothorax and blood sputum in the experimental group was higher than that in the control group (χ2 = 6.031, P < 0.05). However, no significant differences were found regarding other common complications of microwave ablation and chemotherapy.

Conclusions: Chemotherapy combined with intermittent microwave ablation is superior to chemotherapy alone in improving the rate of disease control and the quality of life of patients, as well as prolonging the PFS of patients.

Methods: A total of 34 cases of oligometastatic NSCLC who received chemotherapy with intermittent CT guided microwave ablation and 33 cases of oligometastatic NSCLC patients who received chemotherapy only were enrolled. The efficacy and the adverse effects were evaluated.


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