Research Papers:

Dual trigger of triptorelin and HCG optimizes clinical outcome for high ovarian responder in GnRH-antagonist protocols

Saijiao Li, Danni Zhou, Tailang Yin, Wangming Xu, Qingzhen Xie, Dan Cheng and Jing Yang _

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Oncotarget. 2018; 9:5337-5343. https://doi.org/10.18632/oncotarget.23916

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Saijiao Li1,*, Danni Zhou1,*, Tailang Yin1, Wangming Xu1, Qingzhen Xie1, Dan Cheng1 and Jing Yang1

1Reproductive Medicine Center, Renmin Hospital of Wuhan University, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan, Hubei 430060, P.R. China

*These authors have contributed equally to this work

Correspondence to:

Jing Yang, email: [email protected]

Keywords: dual trigger; GnRH agonist; GnRH antagonist protocols; OHSS; high ovarian response

Received: August 30, 2017    Accepted: December 04, 2017    Published: January 04, 2018


In this paper, a retrospective cohort study was conducted to the high ovarian responders in GnRH-antagonist protocols of IVF/ICSI cycles. The purpose of the study is to investigate whether dual triggering of final oocyte maturation with a combination of gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (HCG) can improve the clinical outcome compared with traditional dose (10000IU) HCG trigger and low-dose (8000IU) HCG trigger for high ovarian responders in GnRH-antagonist in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) cycles. Our study included 226 couples with high ovarian responders in GnRH-antagonist protocols of IVF/ICSI cycles. Standard dosage of HCG trigger (10000 IU of recombinant HCG) versus dual trigger (0.2 mg of triptorelin and 2000 IU of recombinant HCG) and low-dose HCG trigger (8000IU of recombinant HCG) were used for final oocyte maturation. Our main outcome measures were high quality embryo rate, the number of usable embryos, the risk of OHSS, duration of hospitalization and incidence rate of complications. Our evidence demonstrated that dual trigger is capable of preventing severe OHSS while still maintaining excellent high quality embryo rate in in high ovarian responders of GnRH-antagonist protocols.

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