Oncotarget

Clinical Research Papers:

Dietary patterns and primary liver cancer in Chinese adults: a case-control study

Qiu-Ye Lan _, Gong-Cheng Liao, Rui-Fen Zhou, Pei-Yan Chen, Xiao-Yan Wang, Min-Shan Chen, Yu-Ming Chen and Hui-Lian Zhu

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Oncotarget. 2018; 9:27872-27881. https://doi.org/10.18632/oncotarget.23910

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Abstract

Qiu-Ye Lan1, Gong-Cheng Liao1, Rui-Fen Zhou1, Pei-Yan Chen1, Xiao-Yan Wang1, Min-Shan Chen2, Yu-Ming Chen1 and Hui-Lian Zhu1

1School of Public Health, Sun Yat-Sen University, Guangzhou 510080, People's Republic of China

2Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, People's Republic of China

Correspondence to:

Hui-Lian Zhu, email: zhuhl@mail.sysu.edu.cn

Keywords: primary liver cancer; factor analysis; dietary pattern

Received: August 09, 2017     Accepted: October 30, 2017     Epub: January 04, 2018     Published: June 12, 2018

ABSTRACT

Introduction: Healthy dietary patterns may prevent many chronic diseases, and is emphasized by 2015 US dietary guideline, but it remains unclear which dietary patterns may be benefit to prevention of primary liver cancer (PLC).

Materials and Methods: We recruited 782 PLC cases and 1:1 age- and sex-matched controls in Guangzhou, China. Habitual dietary intake was assessed by face-to-face interview using a 79-item food frequency questionnaire, and used to explore dietary patterns by factor analysis.

Results: Three dietary patterns were identified: 1) an urban prudent dietary pattern (UPDP) characterized by high in dairy products, eggs, mushrooms, nuts and soy foods, but low in refined grains; 2) a traditional Cantonese dietary pattern (TCDP) consisting of a high intake of fruit and vegetables, fish, Cantonese soup, and Chinese herb tea; and 3) a high meat and preserved food pattern (MPFP). Multivariable analyses showed favorable associations for the first two dietary patterns, but unfavorable association for the last one (all p-trend < 0.01). Odds ratios (95% CI) of PLC for the highest (vs. lowest) quartile of pattern scores of the three patterns were 0.25 (0.18–0.35), 0.61 (0.46–0.82), and 1.98 (1.46–2.69), respectively.

Conclusions: Our findings suggest that the UPDP and TCDP were associated with lower, whereas the MPFP with higher, risk of PLC.


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