Meta-analysis of the relationship between single nucleotide polymorphism of IL-10-1082G/A and rheumatic heart disease
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Weiran Dai1, Ziliang Ye1,2, Haili Lu2, Qiang Su1, Hui Li3 and Lang Li1
1Department of Cardiology, the First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning, Guangxi, China
2Guangxi Medical University, Nanning, Guangxi, China
3Department of Infectious Diseases, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
Lang Li, email: [email protected]
Keywords: IL-10-1082G/A; single nucleotide polymorphism; rheumatic heart disease; correlation; meta-analysis
Received: July 10, 2017 Accepted: November 09, 2017 Published: January 03, 2018
Background: The results showed that there was a certain correlation between the single nucleotide polymorphism of IL-10-1082G/A and rheumatic heart disease, but there was no systematic study to verify this conclusion.
Aims: Systematic review of the association between single nucleotide polymorphism of IL-10-1082G/A locus and rheumatic heart disease.
Materials and Methods: Computer retrieval PubMed, EMbase, Cochrane Library, CBM, CNKI, VIP and Data WanFang, the retrieval time limit from inception to June 2017. A case control study of single nucleotide polymorphisms and rheumatic heart disease in patients with rheumatic heart disease in the IL-10-1082G/A was collected. Two researchers independently screened the literature, extracted data and evaluated the risk of bias in the study, and using RevMan5.3 software for data analysis.
Results: A total of 3 case control studies were included, including 318 patients with rheumatic heart disease and 502 controls. Meta-analysis showed that there was no correlation between IL-10-1082G/A gene polymorphism and rheumatic heart disease [AA+AG VS GG: OR = 0.62, 95% CI (0.28, 1.39), P = 0.25; AA VS AG+GG: OR = 0.73, 95% CI (0.54, 1.00), P = 0.05; AA VS GG: OR = 0.70, 95% CI(0.47, 1.05), P = 0.08; AG VS GG: OR = 0.65, 95% CI (0.22, 1.92), P = 0.43; A VS G: OR = 0.87, 95% CI (0.71, 1.06), P = 0.17].
Conclusions: When AA is a recessive gene, the single nucleotide polymorphism of IL-10-1082G/A is associated with the presence of rheumatic heart disease. Due to the limitations of the quantity and quality of the included literatures, the further research results were still needed.
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