Association between PIK3CA alteration and prognosis of gastric cancer patients: a meta-analysis
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Hua Li1,*, Shubo Chen2,*, Hui Li3,*, Jianxin Cui4,*, Yunhe Gao4, Dianchao Wu1, Shangfeng Luan1, Yan Qin1, Tongshan Zhai1, Dengxiang Liu5 and Zhibin Huo1
1Department of Surgical Oncology, Affiliated Xing Tai People Hospital of Hebei Medial University, Xingtai 054001, China
2Department of Surgical Urology, Affiliated Xing Tai People Hospital of Hebei Medial University, Xingtai 054001, China
3Department of General Surgery, Affiliated Xing Tai People Hospital of Hebei Medial University, Xingtai 054001, China
4Department of General Surgery, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
5Institute of Cancer Control, Affiliated Xing Tai People Hospital of Hebei Medial University, Xingtai 054001, China
*These authors have contributed equally to this work
Zhibin Huo, email: [email protected]
Dengxiang Liu, email: [email protected]
Keywords: PIK3CA; gastric cancer; prognosis; alteration; meta-analysis
Received: August 09, 2017 Accepted: December 26, 2017 Published: January 02, 2018
Background: Increasing evidence suggests that dysregulation of phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) plays an important role in carcinogenesis. However, the relationship between PIK3CA expression and gastric cancer (GC) prognosis remains controversial.
Methods: We searchedPubMed, Embase, Web of Science, and the Cochrane Library databases for relevant studies up to June 30, 2017. Primary outcomes were hazard ratio (HR), odds ratio (OR), and 95% confidence intervals (CI) for association with overall survival and clinicopathological features.
Results: Eleven studies comprising 2481 GC patients were analyzed. Pooled analysis showed that PIK3CA upregulation was significantly associated with worse overall survival (HR = 1.79, 95% CI 1.42–2.27, p< 0.001) at the protein (HR = 1.94, 95% CI 1.52–2.47, p< 0.001) but not the gene (HR = 1.57, 95% CI 0.92–2.69, p= 0.097) level. PIK3CA gene mutation did not correlate with overall survival (HR = 1.05, 95% CI 0.83–1.34, p= 0.666) but was significantly associated with poor tumor differentiation (OR = 0.37, 95% CI 0.17–0.76, p= 0.011).
Conclusion: High PIK3CA protein expression predicted poor prognosis in GC, whereas PIK3CA gene amplification or mutation did not. Moreover, PIK3CA mutation was an indicator of poorly differentiated tumors.
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