Tooth loss and cancer risk: a dose–response meta analysis of prospective cohort studies

Jun Shi _, Weidong Leng, Lunhua Zhao, Cai Deng, Chenli Xu, Jue Wang, Yu Wang and Xingchun Peng

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Oncotarget. 2018; 9:15090-15100. https://doi.org/10.18632/oncotarget.23850

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Jun Shi1, Weidong Leng1, Lunhua Zhao2, Cai Deng1, Chenli Xu2, Jue Wang2, Yu Wang3 and Xingchun Peng2,3,4

1Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China

2School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei, 442000, China

3Department of Ultrasonography, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, Hubei, 441000, China

4Department of Oncology, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, 441300, China

Correspondence to:

Xingchun Peng, email: [email protected]

Yu Wang, email: [email protected]

Keywords: cancer; tooth loss; dose–response relationship; meta analysis

Received: April 27, 2017     Accepted: October 25, 2017     Epub: December 16, 2017     Published: March 13, 2018


Conflicting results to identify the relationship between tooth loss and cancer risk. Therefore, a dose-response meta-analysis was performed to clarify and quantitative assessed the correlation between tooth loss and cancer risk. Up to March 2017, 25 observational epidemiological studies were included in current meta-analysis. Tooth loss was significantly associated with a higher risk of cancer. Additionally, tooth loss was associated with significantly a higher risk of esophageal cancer, gastric cancer, head and neck cancer, colorectal cancer, pancreas cancer, lung cancer, prostate cancer, bladder cancer and hematopoietic cancer. Subgroup analysis showed consistent findings. Furthermore, a significant dose-response relationship was observed between tooth loss and cancer risk. Increasing per 10 of tooth loss was associated with a 9% increment of cancer risk, 14% increment of esophageal cancer risk, 9% increment of gastric cancer risk, 31% increment of head and neck cancer risk, 4% increment of colorectal cancer risk, 7% increment of pancreas cancer risk, 19% increment of lung cancer risk, 2% increment of bladder cancer risk and 3% increment of hematopoietic cancer risk. Considering these promising results, tooth loss might be harmful for health. Large sample size, different ethnic population and different cancer type are warranted to validate this association.

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