Oncotarget

Research Papers:

Genetic polymorphisms in HLA-DP and STAT4 are associated with IgA nephropathy in a Southwest Chinese population

Bin Yang, Junlong Zhang, Xinle Liu, Zhuochun Huang, Zhenzhen Su, Yun Liao and Lanlan Wang _

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Oncotarget. 2018; 9:7066-7074. https://doi.org/10.18632/oncotarget.23829

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Abstract

Bin Yang1,*, Junlong Zhang1,*, Xinle Liu1,*, Zhuochun Huang1, Zhenzhen Su1, Yun Liao1 and Lanlan Wang1

1Department of Lab Medicine, West China Hospital, Sichuan University, Sichuan 610041, Chengdu, China

*These authors contributed equally to this work

Correspondence to:

Lanlan Wang, email: wanglanlan_lab@163.com

Keywords: genetic polymorphisms; HLA-DP/DQ; STAT4; IgA nephropathy

Received: January 12, 2017     Accepted: December 28, 2017     Published: January 02, 2018

ABSTRACT

IgA nephropathy (IgAN) is the most common chronic glomerular disease worldwide. Genetic factors are thought to be crucial in the pathogenesis of IgAN. However, few data are available on the relationship between human leucocyte antigen (HLA) and signal transducer and activator of transcription 4 (STAT4) polymorphisms and IgAN susceptibility in the Chinese population. Therefore, we examined HLA-DP/DQ and STAT4 polymorphisms (rs3077, rs9277535, rs7453920 and rs7574865) in a total of 630 subjects including 140 IgAN and 490 healthy controls in Chinese. There were significant associations between IgAN patients and healthy controls in the allele frequency of rs3077, rs9277535 and rs7574865. In addition, the genotypes of rs3077, rs9277535 and rs7574865 were also significantly associated with IgAN under recessive models. Moreover, the haplotypes block AAG, AGG, GAG and GGA in the HLA gene significantly correlated with the risk of IgAN. This is the first study demonstrating the significant associations of SNP rs3077, rs9277535 and rs7574865 and the haplotypes in the HLA gene with the risk of IgAN in a Southwest Chinese population. This research provides a new insight into the significant relationship between HLA-DP and STAT4 polymorphisms and the susceptibility to IgAN.


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