Clinical Research Papers:
Polymorphisms in BER genes and risk of breast cancer: evidences from 69 studies with 33760 cases and 33252 controls
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Lele Qiao1,*, Xiaoshan Feng1,*, Gongping Wang1, Bo Zhou1, Yantong Yang1 and Mengxiang Li2
1The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China
2Henan University of Science and Technology, LuoYang, Henan, 471023, China
*These authors contributed equally to this work and should be considered as co-first authors
Lele Qiao, email: [email protected]
Xiaoshan Feng, email: [email protected]
Keywords: BER gene; breast cancer; polymorphism; meta-analysis
Received: June 27, 2017 Accepted: November 27, 2017 Epub: January 02, 2018 Published: March 23, 2018
Recently, numerous studies have reported an association between single nucleotide polymorphisms in base-excision repair genes and the risk of developing breast cancer, however there is no consensus. The aim of this meta-analysis was to review and quantitatively assess the relationship between single nucleotide polymorphisms in base-excision repair genes and breast cancer risk. The results suggested that a mutation of T to G in rs1760944 may lead to a higher risk of developing breast cancer in the Mongoloid population, and G to A of rs25487 significantly reduced the risk of breast cancer in Mongoloid and Caucasoid populations. In contrast to the CC and CG genotypes, the GG genotype of rs1052133 located on theOGG1 gene appeared to be a protective factor against developing breast cancer in both Mongoloid and Caucasoid populations. There was no evidence to suggest that rs25489, rs1799782, rs1130409, rs1805414 and rs1136410 were associated with breast cancer risk. In conclusion, this study provides evidence to support the theory that DNA repair genes are associated with breast cancer risk, providing information to further understand breast cancer etiology. and The potential biological pathways linking DNA repair, ethnic background, environment and breast cancer require further investigation.
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