Oncotarget

Research Papers:

Association between CYP17 T-34C rs743572 and breast cancer risk

Jing Sun, Hong Zhang, Meiyan Gao, Zhishu Tang, Dongyan Guo, Xiaofei Zhang, Zhu Wang, Ruiping Li, Yan Liu, Wansen Sun _ and Xi Sun

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Oncotarget. 2018; 9:4200-4213. https://doi.org/10.18632/oncotarget.23688

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Abstract

Jing Sun1,*, Hong Zhang2,*, Meiyan Gao3,*, Zhishu Tang1, Dongyan Guo4, Xiaofei Zhang4, Zhu Wang5, Ruiping Li5, Yan Liu5, Wansen Sun5 and Xi Sun6

1Department of Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China

2Department of Neurology, Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China

3Clinical Laboratory, Shaanxi Provincial Hospital of traditional Chinese medicine, Xi'an, Shaanxi, China

4College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China

5Department of Integrated Traditional Chinese and Western Medicine, Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, China

6Department of General Medicine, Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi'an, Shaanxi, China

*These authors contributed equally to this work

Correspondence to:

Wansen Sun, email: [email protected]

Xi Sun, email: [email protected]

Keywords: breast cancer; rs743572; polymorphism

Received: September 04, 2017     Accepted: December 18, 2017     Published: December 26, 2017

ABSTRACT

Association between CYP17 T-34C (rs743572) polymorphism and breast cancer (BC) risk was controversial. In order to derive a more definitive conclusion, we performed this meta-analysis. We searched in the databases of PubMed, EMBASE and Cochrane for eligible publications. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were used to assess the strength of association between CYP17 T-34C polymorphism and breast cancer risk. Forty-nine studies involving 2,7104 cases and 3,4218 control subjects were included in this meta-analysis. In overall, no significant association between CYP17 T-34C polymorphism and breast cancer susceptibility was found among general populations. In the stratified analysis by ethnicity and source, significant associations were still not detected in all genetic models; besides, limiting the analysis to studies with controls in agreement with HWE, we also observed no association between CYP17 T-34C polymorphism and breast cancer risk. For premenopausal women, we didn't detect an association between rs743572 and breast cancer risk; however, among postmenopausal women, we observed that the association was statistically significant under the allele contrast genetic model (OR = 1.10, 95% CI = 1.03–1.17, P = 0.003), but not in other four models. In conclusion, rs743572 may increase breast cancer risk in postmenopausal individuals, but not in premenopausal folks and general populations.


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