The role of exosomal non-coding RNAs in cancer metastasis

Jin-Peng Wang, Yan-Yan Tang, Chun-Mei Fan, Can Guo, Yan-Hong Zhou, Zheng Li, Xiao-Ling Li, Yong Li, Gui-Yuan Li, Wei Xiong, Zhao-Yang Zeng and Fang Xiong _

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Oncotarget. 2018; 9:12487-12502. https://doi.org/10.18632/oncotarget.23552

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Jin-Peng Wang1,2,3, Yan-Yan Tang1,2, Chun-Mei Fan2, Can Guo2, Yan-Hong Zhou2, Zheng Li2, Xiao-Ling Li2, Yong Li2,4, Gui-Yuan Li1,2,3, Wei Xiong1,2,3, Zhao-Yang Zeng1,2,3 and Fang Xiong1

1The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China

2The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China

3Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

4Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

Correspondence to:

Fang Xiong, email: [email protected]

Zhao-Yang Zeng, email: [email protected]

Keywords: exosome; non-coding RNA; tumor microenvironment; tumor metastasis

Received: July 10, 2017     Accepted: October 28, 2017     Published: December 21, 2017


An increasing number of studies has confirmed that many cells can secrete vesicles or exosomes in eukaryotes, which contain important nucleic acids, proteins and lipids and play important roles in cell communication and tumor metastasis. This paper summarizes the comprehensive function of exosomal non-coding RNAs. Although some studies have shown that exosomes mediate tumor signal transduction, the functional mechanism of the tumor metastasis remains to be elucidated. In this paper, we reviewed the role of exosomal non-coding RNAs in mediating cancer metastasis in the tumor microenvironment to provide new ideas for the study of tumor pathophysiology.

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