Oncotarget

Meta-Analysis:

A meta-analysis of the lymphatic microvessel density and survival in gastric cancer with 1809 cases

Liang Liang, Wen-Ting Huang, Rong-Quan He, Hai-Wei Liang, Chun-Qin Huang, Hong Zhou, Fang-Lin Wei, Sheng-Sheng Zhou, Zhi-Gang Peng, Gang Chen, Jun-Qiang Chen and Xin-Gan Qin _

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Oncotarget. 2018; 9:5406-5415. https://doi.org/10.18632/oncotarget.23526

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Abstract

Liang Liang1, Wen-Ting Huang2, Rong-Quan He3, Hai-Wei Liang2, Chun-Qin Huang2, Hong Zhou2, Fang-Lin Wei2, Sheng-Sheng Zhou3, Zhi-Gang Peng3, Gang Chen2, Jun-Qiang Chen1 and Xin-Gan Qin1

1Department of Gastrointestinal Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China

2Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China

3Department of Medical Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China

Correspondence to:

Xin-Gan Qin, email: qinxingan_gxmu@163.com

Keywords: lymphatic microvessel density; gastric cancer; prognosis; meta-analysis

Received: August 03, 2017     Accepted: December 04, 2017     Published: December 21, 2017

ABSTRACT

Lymph node metastasis commonly occurs in gastric cancer. Previous studies have demonstrated that the overexpression of lymphatic microvessel density (LVD) is correlated with various malignancies. To evaluate the potential role of LVD in various malignancies, we conducted a systematic review and meta-analysis to thoroughly investigate the association of LVD expression with tumor progression and survival in gastric cancer. We performed a comprehensive search of common databases and selected studies demonstrating the relationship between LVD expression and gastric cancer prognosis. Hazard ratios (HR) were used to determine the value of LVD for predicting gastric cancer metastasis and prognosis. The data were extracted from the included studies and pooled with the appropriate effects model using STATA 12.0. The results showed that high LVD expression obviously impacted the prognosis of gastric cancer, based on an overall survival (OS) HR of 2.58 (95% CI: 1.91–3.48, P < 0.001) and a disease-free survival (DFS) HR of 2.51 (95% CI: 1.35–4.68, P = 0.004) in the univariate analysis. In addition, the results of the multivariate analysis indicated a remarkable relationship between high LVD expression and gastric neoplasm prognosis. The pooled OS HR was 4.12 (95% CI: 3.45–4.91, P < 0.001). The current meta-analysis shows that high LVD is closely related to tumor metastasis and poor prognosis in gastric malignancy. LVD could be a key factor in tumor lymphatic metastasis. Moreover, LVD is likely a potential index and an effective biomarker for the prediction of patient prognosis.


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