Oncotarget

Research Papers:

Arsenic exposure assists ccm3 genetic polymorphism in elevating blood pressure

Yanfang Gao, Zhiqiang Zhao, Linqing Yang, Xinxia Liu, Xiumei Xing, Huimin Zhang, Jianpei Yun, Xiaoyan Ou, Xiaolin Su, Yao Lu, Yi Sun, Yarui Yang, Jun Jiang, Dong Cui, Zhixiong Zhuang and Yun He _

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Oncotarget. 2018; 9:4915-4923. https://doi.org/10.18632/oncotarget.23518

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Abstract

Yanfang Gao1,3,*, Zhiqiang Zhao1,*, Linqing Yang2,*, Xinxia Liu4, Xiumei Xing1, Huimin Zhang2, Jianpei Yun5, Xiaoyan Ou1, Xiaolin Su1, Yao Lu1, Yi Sun1, Yarui Yang1, Jun Jiang1, Dong Cui1, Zhixiong Zhuang2 and Yun He1

1Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, Sun Yat-sen University School of Public Health, Guangzhou, Guangdong 510080, China

2Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong 518055, China

3Gannan Medical University, Ganzhou, Jiangxi 341000, China

4Zhongshan Center for Disease Control and Prevention, Zhongshan, Guangdong 528400, China

5Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, Guangdong 518020, China

*These authors have contributed equally to this work

Correspondence to:

Yun He, email: heyun7@mail.sysu.edu.cn

Zhixiong Zhuang, email: zxzhuang2007@126.com

Keywords: arsemic exposure; CCM3; genetic polymorphism; blood presssure

Received: May 09, 2017    Accepted: December 05, 2017    Published: December 21, 2017

ABSTRACT

Epidemiologic study has suggested that arsenic exposure is positively related to increased blood pressure. However, the underlying mechanism concerning interaction between genetic polymorphisms and arsenic exposure remains unclear. In present study, within 395 Chinese, the effects of interaction between arsenic exposure and CCM3 gene polymorphisms on elevation of blood pressure were probed by multiple Logistic regression models after adjusting for confounding factors. Firstly, we found that serum arsenic was positively associated with blood pressure, cholesterol, glucose and C-reactive protein. Then, adjusted for confounding factors of age, gender, smoking, alcohol consumption, BMI and degree of education, arsenic exposure incurred the hazard of increased systolic pressure and diastolic pressure, with odds ratios (ORs) being 1.725 and 1.425, respectively. Distinctly, we found that interactions between rs3804610* rs9818496, rs6784267*rs9818496, and rs3804610* rs6784267 variant genotype can increase significantly risks of SBP. Additionally, interactions between rs9818496, rs3804610 and rs6784267 genotypic variantions and arsenic exposure boosted the hazard of increased systolic pressure, with ORs being 1.496, 1.496 and 1.312. In conclusion, our fingdings suggest that As exposure of population can assist CCM3 polymorphism in elevating SBP.


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