Oncotarget

Research Papers:

Prognostic factors for olfactory groove meningioma with nasal cavity extension

Ji Zhang, Ke Sai, Zheng-Quan Zhu, Fu Hua Lin, Zi-Feng Wang, Yong-Ming Chen, Chun-Yu Huang, Yun-Lin Ye, Xiao-Li Wang, You-Ping Li, Shu-Xin Sun, Wei-Ying Zhong, Jian-Bin Chen and Yun-Qiang Yang _

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Oncotarget. 2018; 9:4607-4613. https://doi.org/10.18632/oncotarget.23461

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Abstract

Ji Zhang1,*, Ke Sai1,*, Zheng-Quan Zhu2,*, Fu Hua Lin1,*, Zi-Feng Wang3,*, Yong-Ming Chen4,*, Chun-Yu Huang5,*, Yun-Lin Ye6,*, Xiao-Li Wang7,*, You-Ping Li8,*, Shu-Xin Sun1,*, Wei-Ying Zhong9,*, Jian-Bin Chen10,* and Yun-Qiang Yang11

1Department of Neurosurgery, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

2Department of Neurosurgery, Tumor Hospital Affiliated of Xinjiang Medical University, Ürümqi, China

3State Key Laboratory of Oncology in South China, The Cancer Center of Sun Yat-sen University, Collaborative Innovation Center of Oncology, Guangzhou, China

4Department of Gastric Surgery, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

5Department of Endoscopy, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

6Department of Urology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

7Department of General Surgery, Shang Jin Nan Fu Hospital, West China Hospital, Sichuan University, Chengdu, Sichuan, China

8Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

9Department of Neurosurgery, Qilu Hospital, Shandong University, Jinan, China

10Department of Neurosurgery, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

11Department of Oral and Maxillofacial Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

*These authors contributed equally to this work

Correspondence to:

Yun-Qiang Yang, email: yangyun720@163.com

Keywords: olfactory groove meningioma; communicating; recurrence; prognosis factors

Received: August 06, 2017     Accepted: November 28, 2017     Published: December 19, 2017

ABSTRACT

Objectives: Meningioma recurrence remains a significant issue. No study has described the relationship between the clinical features and prognosis of communicating meningioma that primarily originates from the olfactory groove. The aim of the study was to identify prognostic factors of communicating olfactory groove meningiomas that could be stratified according to their risk of recurrence.

Results: A Simpson grade one or two resection was achieved. Complications with cerebrospinal rhinorrhoea occurred in two patients: one required reoperation, and the other was managed successfully with external drainage of lumbar cistern. There were 5 known clinical recurrences within the median follow-up of more than 5 years. The median 5-year recurrence-free survival for patients was 88.4%. Factors such as gender, tumour size, T2 signal and the hyperostotic bone had no significant effect on recurrence-free survival. However, recurrence was activated by oedema range, hyperostosis, dural tail sign and tumor texture (p < 0.05). Interestingly, female patients with the disease were younger than males at diagnosis, and the difference was statistically significant (p = 0.013).

Conclusions: Based on these features of communicating olfactory groove meningiomas, different strategies may be adopted for the follow-up and subsequent treatment. Due to the relatively uncommon incidence, more investigations into the clinical behaviour of this entity are crucial.

Patients and Methods: A retrospective study of 43 patients harbouring olfactory groove meningiomas invading the ethmoid or nasal cavity was conducted at three medical centers from 2000 to 2010. The records were reviewed for clinical presentations, imaging studies, surgical observation, histological features and follow-up.


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